Statement of Financial Position [Abstract] ASSETS ASSETS [Abstract] Current assets: Current assets: [Abstract] Cash and cash equivalents Investment securities – available for sale, at fair value Accrued interest receivable on investment securities Advances and deposits for investigator grants Other current assets Total current assets Property and equipment (at cost, less accumulated depreciation of $1,074,961 and $924,961, respectively) Other assets: Other assets: [Abstract] Deposits, deferred fees and other assets Patent licensing fees, net Total other assets Total assets LIABILITIES AND STOCKHOLDERS' EQUITY LIABILITIES AND STOCKHOLDERS' EQUITY [Abstract] Current liabilities: Current liabilities: [Abstract] Accounts payable Accrued liabilities Notes payable - current portion Deferred revenue - current portion Total current liabilities Carrying value as of the balance sheet date of common stock warrant liability. Common stock warrant liability Notes payable – non-current portion Deferred revenue - non-current portion Other non-current liabilities Total liabilities Stockholders' equity: Stockholders' equity: [Abstract] Common stock, $0.01 par value; 75,000,000 shares authorized; 61,823,340 and 37,967,708 shares issued at June 30, 2013 and December 31, 2012 and 61,160,961 and 37,302,785 shares outstanding at June 30, 2013 and December 31, 2012, respectively Additional paid-in capital Accumulated other comprehensive loss Accumulated deficit Subtotal Treasury stock, at cost (662,379 and 664,921 shares at June 30, 2013 and December 31, 2012, respectively) Total stockholders' equity Total liabilities and stockholders' equity Accumulated Depreciation (in Dollars) Preferred stock, par value (in Dollars per share) Preferred stock, shares authorized Preferred stock, shares issued Preferred stock, shares outstanding Common stock, par value (in Dollars per share) Common stock, shares authorized Common stock, shares issued Common stock, shares outstanding Treasury stock, shares Income Statement [Abstract] Licensing revenue Operating expenses: Operating expenses: [Abstract] Research and development General and administrative Total operating expenses Loss from operations Other income (expense): Other income (expense): [Abstract] The amount recognized in earnings related to the change in fair value during the period of common stock warrant liability. Gain (loss) from change in valuation of common stock warrant liability Investment income, net Interest expense Other expense Total other income (expense), net Net income (loss) Non-cash deemed dividend from beneficial conversion feature on convertible preferred stock Net income (loss) attributable to common shareholders Net income (loss) attributable to common shareholders per common share Net income (loss) attributable to common shareholders per common share [Abstract] Basic (in Dollars per share) Diluted (in Dollars per share) Weighted average shares outstanding Weighted average shares outstanding [Abstract] Basic (in Shares) Diluted (in Shares) Statement of Comprehensive Income [Abstract] Balance Sheet Location [Domain] Other comprehensive loss Other comprehensive loss [Abstract] Changes in: Changes in: [Abstract] Realized loss on investment securities recognized in investment income, net Unrealized loss on investment securities Other comprehensive loss Net income (loss) Total comprehensive income (loss) Statement of Cash Flows [Abstract] Major Types of Debt and Equity Securities [Domain] Cash flows from operating activities: Cash flows from operating activities: [Abstract] Net loss Non-cash items included in net loss: Non-cash items included in net loss: [Abstract] Depreciation and amortization The non-cash amount recognized in earnings related to the change in fair value during the period of common stock warrant liability. Change in fair value of common stock warrant liability Deferred revenue Stock-based compensation Fair value of shares issued from treasury stock for 401K matching contributions. Treasury shares issued for services and 401(k) matching contribution Change in deferred rent liability Deferred finance charges. Deferred finance charges Cash received for non-refundable research and development fee. Cash received for non-refundable research and development fee Net changes in: Net changes in: [Abstract] Accrued interest on short term investments and other current assets Accounts payable Accrued liabilities Net cash used in operating activities: Cash flows from investing activities: Cash flows from investing activities: [Abstract] Purchases of investment securities Proceeds from sale and maturity of investment securities Refund of deposit for letter of credit. Refund of deposit for letter of credit Purchases of property and equipment Net cash used in investing activities Cash flows from financing activities: Cash flows from financing activities: [Abstract] Proceeds from sale of preferred stock, net of issuance costs Proceeds from sale of common stock equity, net of issuance costs Proceeds from exercise of common stock warrants Proceeds from exercise of options to purchase common stock Proceeds from note payable Principal payments on notes payable Net cash provided by financing activities Decrease in cash and cash equivalents Cash and cash equivalents at beginning of period Cash and cash equivalents at end of period Supplemental disclosures of cash flow information: Supplemental disclosures of cash flow information: [Abstract] Interest paid Disclosure Text Block [Abstract] Nature of Operations [Text Block] Basis of Presentation and Significant Accounting Policies [Text Block] Description of New Accounting Pronouncements Not yet Adopted [Text Block] Earnings Per Share [Abstract] Earnings Per Share [Text Block] Investments, Debt and Equity Securities [Abstract] Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block] Fair Value Disclosures [Abstract] Fair Value Disclosures [Text Block] Payables and Accruals [Abstract] Accounts Payable and Accrued Liabilities Disclosure [Text Block] Debt Disclosure [Abstract] Debt Disclosure [Text Block] Stockholders' Equity Note [Abstract] Stockholders' Equity Note Disclosure [Text Block] Disclosure of Compensation Related Costs, Share-based Payments [Abstract] Disclosure of Compensation Related Costs, Share-based Payments [Text Block] Warrants [Abstract] Warrants [Abstract] The entire disclosure for warrant liabilities. Warrants [Text Block] Commitments and Contingencies Disclosure [Abstract] Commitments and Contingencies Disclosure [Text Block] Licensing Transaction [Abstract] Licensing Transaction [Abstract] The entire disclosure for a contractual arrangement, in which the Company gave another party an exclusive license. Licensing Transaction [Text Block] Accounting Policies [Abstract] Business Description and Basis of Presentation [Text Block] Basis of Accounting, Policy [Policy Text Block] New Accounting Pronouncements, Policy [Policy Text Block] Schedule of Accumulated Other Comprehensive Income (Loss) [Table Text Block] Available-for-sale Securities [Table Text Block] Available-for-sale Securities, Continuous Unrealized Loss Position, Fair Value [Table Text Block] Investment Income [Table Text Block] Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block] Schedule of Accrued Liabilities [Table Text Block] Schedule of Maturities of Long-term Debt [Table Text Block] Plan Name [Domain] Note 9 - Stockholders' Equity (Tables) [Table] Note 9 - Stockholders' Equity (Tables) [Line Items] Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block] Schedule of Share-based Payment Award, Employee Stock Purchase Plan, Valuation Assumptions [Table Text Block] Schedule of Shar-based Compensation, Stock Options and Restricted Stock Awards, Activity [Table Text Block] Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block] Schedule of Common Stock Warranty Liability [Table Text Block] Changes in Components of Accumulated Other Comprehensive Loss Changes in Components of Accumulated Other Comprehensive Loss [Abstract] Balance Balance Other comprehensive loss before reclassifications Realized loss reclassified from other accumulated comprehensive loss Net other comprehensive loss Short-term Investment by Bond Maturities Short-term Investment by Bond Maturities [Abstract] Maturities [Domain] Schedule of Available-for-sale Securities [Table] Schedule of Available-for-sale Securities [Line Items] Corporate bond maturities Corporate bond maturities [Abstract] Cost Fair value Short-term Investment - Continuous Unrealized Loss Position Short-term Investment - Continuous Unrealized Loss Position [Abstract] Note 5 - Investment Securities - Available For Sale (Details) - Short-term Investment - Continuous Unrealized Loss Position [Table] Note 5 - Investment Securities - Available For Sale (Details) - Short-term Investment - Continuous Unrealized Loss Position [Line Items] Available for Sale Available for Sale [Abstract] Bonds – corporate issuances (all unrealized holding losses are less than 12 months at date of measurement) Bonds – corporate issuances (all unrealized holding losses are less than 12 months at date of measurement) Bonds – corporate issuances (all unrealized holding losses are less than 12 months at date of measurement) Bonds – corporate issuances (all unrealized holding losses are less than 12 months at date of measurement) Investment Income Investment Income [Abstract] Interest and dividend income Realized losses