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  <xs:element name="ProceedsFromIssuanceOfWarrantsNet" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="clsn_ProceedsFromIssuanceOfWarrantsNet"/>
  <xs:element name="CommonStockAndWarrantsIssuedShares" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="clsn_CommonStockAndWarrantsIssuedShares"/>
  <xs:element name="LeaseTerm" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="clsn_LeaseTerm"/>
  <xs:element name="NumberOfMonthsInWhichFreeRentIsProvided" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="clsn_NumberOfMonthsInWhichFreeRentIsProvided"/>
  <xs:element name="LetterOfCreditRequiredByLeaseFaceAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="clsn_LetterOfCreditRequiredByLeaseFaceAmount"/>
  <xs:element name="ReductionAmountOnLetterOfCreditRequiredByLease" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="clsn_ReductionAmountOnLetterOfCreditRequiredByLease"/>
  <xs:element name="LetteOfCreditAmountRemainingUntilLeaseTermExpires" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="clsn_LetteOfCreditAmountRemainingUntilLeaseTermExpires"/>
  <xs:element name="ReductionofEscrowDeposit" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="clsn_ReductionofEscrowDeposit"/>
  <xs:element name="SupplyCommitmentDomain" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="clsn_SupplyCommitmentDomain"/>
  <xs:element name="Note13TechnologyDevelopmentandLicensingAgreementsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="clsn_Note13TechnologyDevelopmentandLicensingAgreementsDetailsTable"/>
  <xs:element name="Note13TechnologyDevelopmentandLicensingAgreementsDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="clsn_Note13TechnologyDevelopmentandLicensingAgreementsDetailsLineItems"/>
  <xs:element name="DeferredRevenueAmortizationPeriod" type="xbrli:integerItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="clsn_DeferredRevenueAmortizationPeriod"/>
  <xs:element name="ReductionInMilestonePayments" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="clsn_ReductionInMilestonePayments"/>
  <xs:element name="CapitalLeaseTransactionAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem" id="clsn_CapitalLeaseTransactionAxis"/>
  <xs:element name="MaturitiesAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem" id="clsn_MaturitiesAxis"/>
  <xs:element name="ReverseStockSplitMember" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="clsn_ReverseStockSplitMember"/>
  <xs:element name="NovTwoThousandSeventeenMember" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="clsn_NovTwoThousandSeventeenMember"/>
  <xs:element name="WarrantLiabilityMember" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="clsn_WarrantLiabilityMember"/>
  <xs:element name="CommonStockWarrantsMember" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="clsn_CommonStockWarrantsMember"/>
  <xs:element name="YakultAgreementMember" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="clsn_YakultAgreementMember"/>
  <xs:element name="November2011CapitalLeaseMember" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="clsn_November2011CapitalLeaseMember"/>
  <xs:element name="JulySixTwoThousandSixteenMember" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="clsn_JulySixTwoThousandSixteenMember"/>
  <xs:element name="SeriesAConvertiblePreferredStockMember" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="clsn_SeriesAConvertiblePreferredStockMember"/>
  <xs:element name="WaivedWarrantMember" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="clsn_WaivedWarrantMember"/>
  <xs:element name="BetweenThreeToTwelveMonthsMember" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="clsn_BetweenThreeToTwelveMonthsMember"/>
  <xs:element name="OtherIncomeNetMember" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="clsn_OtherIncomeNetMember"/>
  <xs:element name="MayOfferingMember" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="clsn_MayOfferingMember"/>
  <xs:element name="HisunMember" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="clsn_HisunMember"/>
  <xs:element name="FebTwoThousandEighteenMember" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="clsn_FebTwoThousandEighteenMember"/>
  <xs:element name="StockOptionPlansMember" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="clsn_StockOptionPlansMember"/>
  <xs:element name="WithinThreeMonthsMember" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="clsn_WithinThreeMonthsMember"/>
  <xs:element name="CreditAgreementMember" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="clsn_CreditAgreementMember"/>
  <xs:element name="October2009CapitalLeaseMember" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="clsn_October2009CapitalLeaseMember"/>
  <xs:element name="TermALoanMember" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="clsn_TermALoanMember"/>
  <xs:element name="JulyTwoFiveTwoThousandSixteenMember" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="clsn_JulyTwoFiveTwoThousandSixteenMember"/>
  <xs:element name="BondmaturitiesMember" type="nonnum:domainItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="clsn_BondmaturitiesMember"/>
  <xs:element name="DocumentAndEntityInformationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="clsn_DocumentAndEntityInformationAbstract"/>
</xs:schema>
