Equity Components [Axis]
Common Stock [Member]
Additional Paid-in Capital [Member]
Treasury Stock [Member]
AOCI Attributable to Parent [Member]
Retained Earnings [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Hisun Agreement [Member]
Geographical [Axis]
New Jersey [Member]
Subsequent Event Type [Axis]
Subsequent Event [Member]
Statistical Measurement [Axis]
Minimum [Member]
Maximum [Member]
Accounting Standards Update [Axis]
Accounting Standards Update 2016-02 [Member]
Horizon Credit Agreement [Member]
Legal Entity [Axis]
Horizon Technology Finance Corporation [Member]
SVB Loan Facility [Member]
Variable Rate [Axis]
London Interbank Offered Rate (LIBOR) [Member]
Amendment to Horizon Credit Agreement [Member]
Related Party [Axis]
Silicon Valley Bank [Member]
Prime Rate [Member]
Financial Instrument [Axis]
US Treasury Securities [Member]
Corporate Debt Securities [Member]
Measurement Frequency [Axis]
Fair Value, Recurring [Member]
Fair Value Hierarchy and NAV [Axis]
Fair Value, Inputs, Level 1 [Member]
Fair Value, Inputs, Level 2 [Member]
Fair Value, Inputs, Level 3 [Member]
Fair Value, Nonrecurring [Member]
Inprocess R&D [Member]
Business Acquisition [Axis]
EGEN Inc [Member]
IPR and D Drug Technology Platforms [Member]
Contingent Consideration by Type [Axis]
Ovarian Cancer [Member]
Glioblastoma Multiforme Brain Cancer [Member]
Purchase Agreement [Member]
2018 Aspire Purchase Agreements [Member]
Asset Class [Axis]
IPR And D [Member]
Goodwill [Member]
Finite-Lived Intangible Assets by Major Class [Axis]
Noncompete Agreements [Member]
Long-Lived Tangible Asset [Axis]
Machinery and Equipment [Member]
Furniture and Fixtures [Member]
Leasehold Improvements [Member]
Horizon Credit Agreement [Member]
Debt Instrument [Axis]
Horizon Credit Agreement Amendment [Member]
Income Tax Authority [Axis]
Federal Income Tax [Member]
Scenario [Axis]
No Expiration [Member]
State and Local Jurisdiction [Member]
Capital on DemandTM Sales Agreement [Member]
Capital on Demand Agreement [Member]
Securities Purchase Agreement [Member]
Original Warrants [Member]
Exchange Agreements [Member]
Warrant [Member]
Underwriting Agreement [Member]
Sale of Stock [Axis]
Underwritten Offering [Member]
LPC Purchase Agreement [Member]
Lincoln Park Capital Fund, LLC [Member]
LPC Commitment Shares [Member]
January 2021 Registered Direct Offering [Member]
March 2021 Registered Direct Offering [Member]
Class of Stock [Axis]
Series A Convertible Redeemable Preferred Stock [Member]
Series B Convertible Redeemable Preferred Stock [Member]
Plan Name [Axis]
2018 Stock Incentive Plan [Member]
2007 Stock Incentive Plan [Member]
Inducement Option Grants [Member]
Title of Individual [Axis]
Five New Employees [Member]
Award Type [Axis]
Restricted Stock [Member]
Equity Stock Awards [Member]
Granted Under 2018 Plan and 2007 Plan [Member]
2018 Plan [Member]
Inducement Awards [Member]
Stock Options and Restricted Stock Awards [Member]
Income Statement Location [Axis]
Research and Development Expense [Member]
General and Administrative Expense [Member]
Share-based Payment Arrangement, Option [Member]
Exercise Price Range [Axis]
Exercise Price One [Member]
Exercise Price Two [Member]
Exercise Price Three [Member]
Amended Asset Purchase Agreement [Member]
Related Party Transaction [Axis]
Within One Year of Achieving Milestone [Member]
EGWC, Inc [Member]
10 Business Days of Achieving Milestone [Member]
Fair Value Earnout Milestone Liability [Member]
Horizon Credit Agreement Amendment [Member]
1st Lease Amendment [Member]
First Year [Member]
Final Year [Member]
2nd Lease Amendment [Member]
EGEN Asset Purchase Agreement [Member]
Huntsville Alabama [Member]
Operating Leases [Member]
License Agreement [Member]
Duke University [Member]
Legal Entity of Counterparty, Type [Axis]
Hisun [Member]
Cover [Abstract]
Document Type
Amendment Flag
Amendment Description
Document Registration Statement
Document Annual Report
Document Quarterly Report
Document Transition Report
Document Shell Company Report
Document Shell Company Event Date
Document Period Start Date
Document Period End Date
Document Fiscal Period Focus
Document Fiscal Year Focus
Current Fiscal Year End Date
Entity File Number
Entity Registrant Name
Entity Central Index Key
Entity Primary SIC Number
Entity Tax Identification Number
Entity Incorporation, State or Country Code
Entity Address, Address Line One
Entity Address, Address Line Two
Entity Address, Address Line Three
Entity Address, City or Town
Entity Address, State or Province
Entity Address, Country
Entity Address, Postal Zip Code
Country Region
City Area Code
Local Phone Number
Extension
Written Communications
Soliciting Material
Pre-commencement Tender Offer
Pre-commencement Issuer Tender Offer
Title of 12(b) Security
No Trading Symbol Flag
Trading Symbol
Security Exchange Name
Title of 12(g) Security
Security Reporting Obligation
Annual Information Form
Audited Annual Financial Statements
Entity Well-known Seasoned Issuer
Entity Voluntary Filers
Entity Current Reporting Status
Entity Interactive Data Current
Entity Filer Category
Entity Small Business
Entity Emerging Growth Company
Elected Not To Use the Extended Transition Period
Document Accounting Standard
Other Reporting Standard Item Number
Entity Shell Company
Entity Public Float
Entity Bankruptcy Proceedings, Reporting Current
Entity Common Stock, Shares Outstanding
Documents Incorporated by Reference
ICFR Auditor Attestation Flag
Auditor Name
Auditor Location
Auditor Firm ID
Statement of Financial Position [Abstract]
ASSETS
Current assets:
Cash and cash equivalents
Investment in debt securities - available for sale, at fair value
Accrued interest receivable on investment securities
Advances and deposits on clinical programs and other current assets
Total current assets
Property and equipment (at cost, less accumulated depreciation and amortization)
Other assets:
Money market investments, restricted cash
Deferred income tax asset
In-process research and development, net
Goodwill
Operating lease right-of-use assets, net
Other intangible assets, net
Deposits and other assets
Total other assets
Total assets
LIABILITIES AND STOCKHOLDERS’ EQUITY
Current liabilities:
Accounts payable – trade
Other accrued liabilities
Notes payable – current portion, net of deferred financing costs
Operating lease liability - current portion
Deferred revenue - current portion
Total current liabilities
Earn-out milestone liability
Notes payable – non-current portion, net of deferred financing costs
Operating lease liability - non-current portion
Deferred revenue - non-current portion
Total liabilities
Commitments and contingencies
Stockholders’ equity:
Preferred Stock - $0.01 par value (100,000 shares authorized, and no shares issued or outstanding at December 31, 2021 and 2020)
Common stock - $0.01 par value (112,500,000 shares authorized; 5,770,538 and 2,713,424 shares issued at December 31, 2021 and 2020, respectively, and 5,770,516 and 2,713,402 shares outstanding at December 31, 2021 and 2020, respectively)
Additional paid-in capital
Accumulated other comprehensive loss
Accumulated deficit
Total stockholders’ equity before treasury stock
Treasury stock, at cost (22 shares at December 31, 2021 and 2020)
Total stockholders’ equity
Total liabilities and stockholders’ equity
Preferred stock, par value
Preferred stock, shares authorized
Preferred stock, shares issued
Preferred stock, shares outstanding
Common stock, par value
Common stock, shares authorized
Common stock, shares issued
Common stock, shares outstanding
Treasury stock, shares
Income Statement [Abstract]
Technology development and licensing revenue
Operating expenses:
Research and development
General and administrative
Total operating expenses
Loss from operations
Other income (expense):
Gain (loss) from change in earn-out milestone liability
Impairment of goodwill and in-process research and development
Loss on debt extinguishment
Investment income, net
Interest expense
Other income
Total other (expense) income, net
Loss before income tax benefit
Income tax benefit
Net loss
Net loss per common share - basic and diluted
Weighted average common shares outstanding - basic and diluted
Net loss
Changes in:
Realized loss (gain) on investment securities recognized in investment income, net
Unrealized gain on investment securities
Other comprehensive loss (gain) income, net
Comprehensive loss
Statement of Cash Flows [Abstract]
Cash flows from operating activities:
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization
Change in fair value of earn-out milestone liability
Fair value of warrants issued in exchange for services
Stock-based compensation
Change in deferred income tax asset
Impairment of goodwill and in-process research and development
Amortization of deferred finance charges and debt discount associated with note payable
Net changes in:
Accrued interest receivable on investment securities
Advances and deposits on clinical programs and other current assets
Other assets
Accounts payable – trade
Deferred revenue
Other accrued liabilities
Net cash used in operating activities
Cash flows from investing activities:
Purchases of investment in debt securities
Proceeds from sale and maturity of investment in debt securities
Purchases of property and equipment
Net cash (used in) provided by investing activities
Cash flows from financing activities:
Proceeds from issuance of common stock equity, net of issuance costs
Proceeds from issuance of common stock upon exercise of warrants
Proceeds from issuance of common stock upon exercise of stock options
Proceeds from notes payable
Payments on notes payable including end-of-term fees
Proceeds from Paycheck Protection Program (“PPP”) loans
Repayments on PPP loans
Net cash provided by financing activities
Change in cash, cash equivalents and restricted cash
Cash, cash equivalents and restricted cash at beginning of year
Cash, cash equivalents and restricted cash at end of year
Supplemental disclosures of cash flow information:
Interest
Cash paid for amounts included in measurement of lease liabilities:
Operating cash flows from lease payments
Non-cash financing and investing activities
Common stock issued to settle accrued bonuses
Fair value of warrants issued in connection with the debt facility, net of cancelled warrants
Realized and unrealized losses (gains), net, on investment in debt securities
Statement [Table]
Statement [Line Items]
Beginning balance, value
Beginning balance, shares
Sale of equity through equity financing facilities
Sale of equity through equity financing facilities, shares
Issuance of common stock upon exercise of options
Issuance of common stock upon exercise of options, shares
Shares issued pursuant to warrant exercises
Shares issued pursuant to warrant exercises, shares
Issuance of common stock upon exercise of options and vesting of stock awards
Issuance of common stock upon exercise of options and vesting of stock awards, shares
Issuance of common stock upon exercise of common stock warrants
Issuance of common stock upon exercise of common stock warrants,shares
Common stock issued to settle accrued bonuses
Common stock issued to settle accrued bonuses, shares
Common stock warrants issued in exchange for services
Stock-based compensation expense
Realized and unrealized gains and losses, net, on investment securities
Ending balance, value
Ending balance, shares
Accounting Policies [Abstract]
SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES
Organization, Consolidation and Presentation of Financial Statements [Abstract]
FINANCIAL CONDITION
Investments, Debt and Equity Securities [Abstract]
INVESTMENTS IN DEBT SECURITIES AVAILABLE FOR SALE
Fair Values Of Financial Instruments
FAIR VALUES OF FINANCIAL INSTRUMENTS
Goodwill and Intangible Assets Disclosure [Abstract]
INTANGIBLE ASSETS
Property, Plant and Equipment [Abstract]
PROPERTY AND EQUIPMENT
Payables and Accruals [Abstract]
OTHER ACCRUED LIABILITIES
Debt Disclosure [Abstract]
NOTES PAYABLE
Income Tax Disclosure [Abstract]
INCOME TAXES
Equity [Abstract]
STOCKHOLDERS’ EQUITY
Share-based Payment Arrangement [Abstract]
STOCK-BASED COMPENSATION
Earn-out Milestone Liability
EARN-OUT MILESTONE LIABILITY
Warrants
WARRANTS
Retirement Benefits [Abstract]
CELSION EMPLOYEE BENEFIT PLANS
Leases
LEASES
Commitments and Contingencies Disclosure [Abstract]
COMMITMENTS AND CONTINGENCIES
Licenses Of Intellectual Property And Patents
LICENSES OF INTELLECTUAL PROPERTY AND PATENTS
Technology Development And Licensing Agreements
TECHNOLOGY DEVELOPMENT AND LICENSING AGREEMENTS
Subsequent Events [Abstract]
SUBSEQUENT EVENTS
Description of Business
Basis of Presentation
Use of Estimates
Revenue Recognition
Cash and Cash Equivalents
Fair Value of Financial Instruments
Short-Term Investments
Property and Equipment
Deposits
In-Process Research and Development, Other Intangible Assets and Goodwill
Impairment or Disposal of Long-Lived Assets
Comprehensive Income (Loss)
Research and Development
Net Loss Per Common Share
Income Taxes
Stock-Based Compensation
Recent Accounting Pronouncements
SCHEDULE OF COST, FAIR VALUE AND MATURITIES OF SHORT TERM INVESTMENTS
SUMMARY OF INVESTMENT SECURITIES GROSS UNREALIZED GAINS (LOSSES)
SUMMARY OF NET REALIZED LOSSES ON SALES OF AVAILABLE FOR SALE SECURITIES AND INVESTMENT INCOME INTEREST AND DIVIDENDS
SCHEDULE OF FAIR VALUE, ASSETS AND LIABILITIES MEASURED ON RECURRING BASIS
SCHEDULE OF FAIR VALUE OF ASSETS ACQUIRED
SUMMARY OF PROPERTY AND EQUIPMENT
SCHEDULE OF OTHER ACCRUED LIABILITIES
SCHEDULE OF FUTURE PRINCIPLE PAYMENTS, NET OF UNAMORTIZED DEBT DISCOUNTS
SCHEDULE OF DEBT
SCHEDULE OF INCOME TAX PROVISION (BENEFIT)
SCHEDULE OF EFFECTIVE INCOME TAX RATE RECONCILIATION
SCHEDULE OF DEFERRED TAX ASSETS AND LIABILITIES
SUMMARY OF STOCK OPTIONS
SUMMARY OF NON-VESTED RESTRICTED STOCK AWARDS
SUMMARY OF STOCK OPTIONS OUTSTANDING
SCHEDULE OF ASSUMPTIONS USED TO DETERMINE FAIR VALUE OF OPTIONS GRANTED
SCHEDULE OF CHANGES IN EARN-OUT MILESTONE LIABILITY
SUMMARY OF WARRANT ACTIVITY
SCHEDULE OF LEASE PAYMENTS AND MATURITY OF OPERATING LEASE LIABILITIES
Property, Plant and Equipment [Table]
Property, Plant and Equipment [Line Items]
Accounts receivable
Contract liabilities
Depreciation
Impairment of property or equipment
Number of shares of common stock issuable upon exercise of warrants and equity awards
[custom:ProceedFromNetOperatingLossesGross]
Net proceeds from sale of net operating losses
Tax benefits of EDA
Proceeds from Contributed Capital
Direct Financing Lease, Selling Loss
Right-of-use assets
Related lease liabilities
Other liabilities
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Cumulated net losses
Cash and cash equivalents, short-term investments
[custom:ReceivableOnSaleOfNetOperatingLosses-0]
Operating Costs and Expenses
Debt Instrument, Description
Debt Instrument, Interest Rate, Stated Percentage
Repayments of Notes Payable
Debt Instrument, Face Amount
Debt instrument related end term charges
Line of Credit Facility, Maximum Borrowing Capacity
Repayment of outstanding in-debtedness amount
Line of Credit Facility, Remaining Borrowing Capacity
Marketable Securities [Table]
Marketable Securities [Line Items]
Short-term investments - Cost
Short-term investments - Fair Value
Short-term investment maturities - Within 3 months, cost
Short-term investment maturities - Within 3 months, fair value
Short-term investment maturities - Between 3-12 months, cost
Short-term investment maturities - Between 3-12 months, fair value
Total, cost
Total, fair value
Investments with unrealized gains, Fair Value
Investments with unrealized gains, Unrealized Holding Gains (Losses)
Investments with unrealized losses, Fair Value
Investments with unrealized Losses, Unrealized Holding Gains (Losses)
Investment securities, available for sale
Investments with unrealized Gains (Losses), Unrealized Holding Gains (Losses)
Interest and dividends accrued and paid
Realized (losses) gains
Investment income net
Fair Value, Recurring and Nonrecurring [Table]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Schedule of Finite-Lived Intangible Assets [Table]
Finite-Lived Intangible Assets [Line Items]
Balance
Amortization
Impairment charge
Balance
Schedule of Restructuring and Related Costs [Table]
Restructuring Cost and Reserve [Line Items]
Indefinite-lived Intangible Assets Acquired
Finite-lived Intangible Assets Acquired
Asset impairment charges
Non-cash charge
Finite-Lived Intangible Asset, Useful Life
Amortization
Finite-Lived Intangible Assets, Net
Goodwill, Acquired During Period
Property and equipment gross
Less accumulated depreciation and amortization
Total
Estimated useful life
Amounts due to contract research organizations and other contractual agreements
Accrued payroll and related benefits
Accrued interest
Accrued professional fees
Other
Total
2022
2023
2024
2025 and thereafter
Subtotal of future principal payments
Unamortized debt premium, net
Total
Principal balance at June 18, 2021
Early termination fees
End of term charges
Total
Schedule of Short-term Debt [Table]
Short-term Debt [Line Items]
Proceeds from Lines of Credit
Restricted Cash
Final payment percentage
Long-term Line of Credit
Financing fees and expenses
End of term charge percentage
Amortization of Debt Issuance Costs
Interest expense
Amortization of Debt Issuance Costs and Discounts
Payment of debt end term charges
Debt instrument face amount
Debt Instrument, Interest Rate Terms
Payments of debt extinguishment costs
Debt Instrument, Fee Amount
Debt Instrument, Restrictive Covenants
Loan Processing Fee
Debt Instrument, Unamortized Discount
Financing fee
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Class of Warrant or Right, Exercise Price of Warrants or Rights
Fair Value Adjustment of Warrants
Class of Warrant or Right, Outstanding
Warrants cancelled
Warrants Not Settleable in Cash, Fair Value Disclosure
End term fees
Gain (Loss) on Contract Termination
Current
Deferred
Current
Deferred
Total
Federal statutory rate
State taxes, net of federal tax benefit
Permanent differences
Other
Change in valuation allowance and deferred rate change, net
Effective tax rate
Net operating loss carryforwards
Other Deferred tax assets, net
Subtotal
Valuation allowance
Total deferred tax asset
Operating Loss Carryforwards [Table]
Operating Loss Carryforwards [Line Items]
Proceeds from sale of nols
Net operating losses
Net operating losses, unused
Net operating losses carryforward limits, description
Net operating losses expiration, description
Operating loss carry forwards, limitation on use
Operating Income (Loss)
Accumulated Other Comprehensive Income (Loss) [Table]
Accumulated Other Comprehensive Income (Loss) [Line Items]
Shelf registration statement amount
Reverse Stock Split
Stockholders equity note changes in capital structure description
Reverse stock split common stock outstanding
Warrants
Less than 12 months, unrealized gains, fair value
Stock Issued During Period, Shares, New Issues
Proceeds from Issuance of Common Stock
Shares Issued, Price Per Share
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right
Proceeds from Issuance of Warrants
Share Price
Underwriting discount price per share
Payments from sale of nols
Placement agent fee description.
Preferred Stock, Shares Issued
Preferred Stock, Par or Stated Value Per Share
Proceeds from Issuance of Preferred Stock and Preference Stock
Preferred Stock, Convertible, Conversion Price
Convertible Preferred Stock, Shares Issued upon Conversion
Preferred Stock Voting Rights
Common Stock, Par or Stated Value Per Share
Preferred Stock Value
Preferred Stock Shares Outstanding
Proceeds From Issuance Under Placement
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number Outstanding, Outstanding, Beginning balance
Weighted Average Exercise Price, Outstanding, Ending balance
Number Outstanding, Options granted
Weighted Average Exercise Price, Options granted
Number Outstanding, Options exercised
Weighted Average Exercise Price, Options exercised
Number Outstanding, Options canceled or expired
Weighted Average Exercise Price, Options canceled or expired
Number Outstanding, Outstanding, Ending balance
Weighted Average Exercise Price, Outstanding, Ending balance
Weighted Average Remaining Contractual Term (years), Outstanding, Ending balance
Aggregate Intrinsic Value, Outstanding, Ending balance
Number Outstanding, Exercisable, Ending balance
Weighted Average Exercise Price, Exercisable, Ending balance
Weighted Average Remaining Contractual Term (years), Exercisable, Ending balance
Aggregate Intrinsic Value, Exercisable, Ending balance
Number Outstanding, Non-vested stock awards, Outstanding, Beginning balance
Weighted Average Grant Date Fair Value, Non-vested stock awards, Outstanding, Beginning balance
Number Outstanding, Non-vested stock awards, Granted
Weighted Average Grant Date Fair Value, Non-vested stock awards, Granted
Number Outstanding, Non-vested stock awards, Vested and issued
Weighted Average Grant Date Fair Value, Non-vested stock awards, Vested and issued
Number Outstanding, Non-vested stock awards, Forfeited
Weighted Average Grant Date Fair Value, Non-vested stock awards, Forfeited
Number Outstanding, Non-vested stock awards, Outstanding, Ending balance
Weighted Average Grant Date Fair Value, Non-vested stock awards, Outstanding, Ending balance
Share-based Payment Arrangement, Option, Exercise Price Range [Table]
Share-based Payment Arrangement, Option, Exercise Price Range [Line Items]
Range of Exercise Prices, Upper
Options Outstanding, Number
Options Outstanding, Weighted Average Remaining Contractual Term (in years)
Options Outstanding, Weighted Average Exercise Price
Options Exercisable, Number
Options Exercisable, Weighted Average Remaining Contractual Term (in years)
Options Exercisable, Weighted Average Exercise Price
Share-based Payment Arrangement, Option, Exercise Price Range, Lower Range Limit
Risk-free interest rate, minimum
Risk-free interest rate, maximum
Expected volatility, minimum
Expected volatility, maximum
Expected life (in years)
Expected dividend yield
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized
Shares Available for Grant
Stock options, strike price description
Shares, Issued
Exercise price per share
Award Vesting Period
Common Stock, Capital Shares Reserved for Future Issuance
Compensation cost
Common Stock, Shares Issued
Unrecognized compensation cost
Cost recognized over a weighted-average period
Schedule Of Changes In Earn-out Milestone Liability
Earn-out liabilities, beginning balance
Non-cash gain loss from the adjustment for the change in fair value
Earn-out liabilities, ending balance
Earnout milestone liability
Earnout payment options description
Warrants to purchase common stock
Warrant price per share
Right to receiving warrant
Business Combination, Consideration Transferred, Liabilities Incurred
Non-cash charge on earnout milestone liability
Summary Of Warrant Activity
Number of Warrants Issued, Warrants outstanding, Beginning balance
Weighted Average Exercise Price, Warrants outstanding, Beginning balance
Number of Warrants Issued, Warrants issued
Weighted Average Exercise Price, Warrants issued
Number of Warrants Issued, Warrants exercised
Weighted Average Exercise Price, Warrants exercised
Number of Warrants Issued, Warrants cancelled
Weighted Average Exercise Price, Warrants cancelled
Number of Warrants Issued, Warrants outstanding, Ending balance
Weighted Average Exercise Price, Warrants outstanding, Ending balance
Aggregate intrinsic value of outstanding warrants
Weighted average remaining contractual terms (years)
Summary Of Warrant Activity Details
Award vesting period
Warrant Price, fair value
Professional fee expense
Maximum annual contributions per employee, percent
Matching contributions of employee
Discretionary contribution
Discretionary contribution, rate
Schedule Of Lease Payments And Maturity Of Operating Lease Liabilities
2022
2023
2024 and thereafter
Subtotal future lease payments
Less imputed interest
Total lease liabilities
Operating Lease, Weighted Average Remaining Lease Term
Operating Lease, Weighted Average Discount Rate, Percent
Lessee, Operating Lease, Description
Area of Land
Lessee, Operating Lease, Term of Contract
Lease Expiration Date
Payments of rent
Operating Lease, Right-of-Use Asset
Operating Lease, Liability
Other Liabilities
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Operating Lease, Cost
Operating Lease, Payments
Number of days before issuance factoring into average closing price
Common stock, shares, issued
Common stock, value, issued
Schedule of Accounts, Notes, Loans and Financing Receivable [Table]
Accounts, Notes, Loans and Financing Receivable [Line Items]
Non-refundable research and development fee
Deferred revenue
Deferred revenue amortization period
Subsequent Event [Table]
Subsequent Event [Line Items]
Investment
Common Stock Shares Outstanding
Gain loss from change in earnout milestone liability.
Impairment of in-process research and development.
Fair value of warrants issued in exchange for services.
Amortization of deferred finance charges and debt discount associated with note payable.
Impairment of in-process research and development.
Payments on notes payable including endofterm fees.
Proceeds from issuance of common stock upon exercise of stock options.
Fair value of warrants issued in connection with debt facility net of cancelled warrants.
Realizedand unrealized gains and losses net on investment in debt securities.
Issuance of common stock upon exercise of options.
Adjustments to additional paid in capitaCommon stock warrants issued in exchange for services
Issuance of common stock upon exercise of options shares.
Stock issued during period, value, Issuance of common stock upon exercise of common stock warrants.
Issuance of common stock upon exercise of common stock warrants, shares.
Common stock issued to settle accrued bonuses.
Common stock issued to settle accrued bonuses, shares.
Description Of Business [Policy Text Block]
Deposits [Policy Text Block]
Hisun Agreement [Member]
Represents the total number of Shares of common stock issuable upon exercise of warrants and equity awards.
Tax benefits of EDA
New Jersey [Member]
Net proceeds from sale of net operating losses
Receivable on sale of net operating losses.
Horizon Credit Agreement [Member]
Horizon Technology Finance Corporation [Member]
SVB Loan Facility [Member]
Amendment to Horizon Credit Agreement [Member]
Debt instrument related end term charges.
Silicon Valley Bank [Member]
Repayment of outstanding indebtedness amount.
The current amount of amortized cost of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).
Amortized cost of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale), with single maturity date and allocated without single maturity date, maturing in next rolling three to twelve months.
Fair value of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale), with single maturity date and allocated without single maturity date, maturing in next rolling three to twelve months.
Amortized cost of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale) with single maturity date and allocated without single maturity date, maturing in next rolling three months.
Fair value of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale), with single maturity date and allocated without single maturity date, maturing in next rolling three months.
Government Backed Debt Securities [Member]
Available for sale securities unrealized gains fair value.
Available for sale securities unrealized losses fair value.
Available for sale securities unrealized gains less than twelve months.
Available for sale securities unrealized losses less than twelve months.
Available for sale securities unrealized gains (losses) less than twelve months.
Investment income loss non operating.
Inprocess R&D [Member]
Information pertaining to the business acquisition of EGEN, Inc.
IPR and D Drug Technology Platforms [Member]
Ovarian Cancer [Member]
Glioblastoma Multiforme Brain Cancer [Member]
Non-cash charge.
Purchase Agreement [Member]
2018 Aspire Purchase Agreements [Member]
IPR And D [Member]
Final Payment Percentage.
End of term charge percentage.
Long-term debt maturities repayments of principal year four and there-after.
Horizon Credit Agreement [Member]
Warrants cancelled.
End of term fees.
Horizon Credit Agreement Amendment [Member]
Early termination fee.
End of term charge.
Effective income tax rate reconciliation permanent differences.
Proceeds From Sale Of Net Operating Losses.
Net operating losses, unused.
Federal Income Tax [Member]
No Expiration [Member]
Net operating losses carryforward limits, description.
Net operating losses expiration, description.
Operating loss carry forwards, limitation on use
Shelf Registration statement amount.
Aggregate offering price.
Capital on DemandTM Sales Agreement [Member]
Capital on Demand Agreement [Member]
Securities Purchase Agreement [Member]
Original Warrants [Member]
Exchange Agreements [Member]
Underwriting Agreement [Member]
Underwritten Offering [Member]
Underwriting discount price per share.
Percentage of underwriting discount on public offering price.
LPC Purchase Agreement [Member]
Lincoln Park Capital Fund, LLC [Member]
LPC Commitment Shares [Member]
January 2021 Registered Direct Offering [Member]
Placement agent fee description.
March 2021 Registered Direct Offering [Member]
Series A Convertible Redeemable Preferred Stock [Member]
Series B Convertible Redeemable Preferred Stock [Member]
2018 Stock Incentive Plan [Member]
Stock options, strike price description.
2007 Stock Incentive Plan [Member]
Inducement Option Grants [Member]
Five New Employees [Member]
Equity Stock Awards [Member]
Granted Under 2018 Plan and 2007 Plan [Member]
2018 Plan [Member]
Inducement Awards [Member]
Stock Options and Restricted Stock Awards [Member]
Exercise Price One [Member]
Exercise Price Two [Member]
Exercise Price Three [Member]
Earnout Milestone Liability Disclosure [Text Block]
Warrants [Text Block]
Schedule Of Changes In Earn Out Milestone Liabilities [Table Text Block]
Earn-out liabilities, beginning balance.
The amount of gain (loss) from the change in the fair value of earn-out milestone liability.
Earnout milestone liability.
Amended Asset Purchase Agreement [Member]
Within One Year of Achieving Milestone [Member]
10 Business Days of Achieving Milestone [Member]
Earn-out payment options, description.
EGWC, Inc [Member]
Fair Value Earnout Milestone Liability [Member]
Non-cash charge on earnout milestone liability.
Horizon Credit Agreement Amendment [Member]
Sharebased compensation arrangement by sharebased payment award non options outstanding intrinsic value.
Weighted average remaining contractual term for non-option awards outstanding, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.
Weighted average price at which grantees can acquire the shares reserved for issuance under the stock non-option equity plan.
Weighted average per share amount at which grantees can acquire shares of common stock by exercise of non-option equity.
Share based compensation arrangement by share based payment award non option equity instruments exercised in period weighted average exercise price.
Share based compensation arrangement by share based payment award non option equity instruments cacel in period weighted average exercise price.
Amount of discretionary contributions made by an employer as a percentage of each participants annual salary to a defined contribution plan.
1st Lease Amendment [Member]
First Year [Member]
Final Year [Member]
2nd Lease Amendment [Member]
EGEN Asset Purchase Agreement [Member]
Huntsville Alabama [Member]
Operating Leases [Member]
Licenses Of Intellectual Property And Patents [Text Block]
Number of days before issuance factoring into average closing price.
License Agreement [Member]
Duke University [Member]
Licensing Transaction [Text Block]
Hisun [Member]
The amortization period for deferred revenue.
Gross Proceeds From Sale Of Net Operating Losses.
Proceed from net operating losses gross.
Horizon Credit Agreement [Member] [Default Label]
Horizon Credit Agreement Amendment [Member] [Default Label]
Assets, Current
Other Assets, Noncurrent
Assets
Liabilities, Current
Liabilities
Stockholders' Equity before Treasury Stock
Treasury Stock, Value
Stockholders' Equity Attributable to Parent
Liabilities and Equity
Operating Expenses
ImpairmentOfGoodwillAndInprocessResearchAndDevelopment
Interest Expense
Nonoperating Income (Expense)
Other Comprehensive Income (Loss), Reclassification Adjustment from AOCI for Sale of Securities, Net of Tax
OCI, Debt Securities, Available-for-Sale, Gain (Loss), after Adjustment and Tax
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Increase (Decrease) in Accrued Investment Income Receivable
Increase (Decrease) in Prepaid Expense and Other Assets
Increase (Decrease) in Other Current Assets
Increase (Decrease) in Accounts Payable, Trade
Increase (Decrease) in Other Accrued Liabilities
Net Cash Provided by (Used in) Operating Activities
Payments to Acquire Debt Securities, Available-for-sale
Payments to Acquire Property, Plant, and Equipment
Net Cash Provided by (Used in) Investing Activities
PaymentsOnNotesPayableIncludingEndoftermFees
Repayments of Debt
Net Cash Provided by (Used in) Financing Activities
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations
Interest Paid, Excluding Capitalized Interest, Operating Activities
Shares, Outstanding
CommonStockIssuanceToSettleAccruedBonuses
InvestmentIncomeLossNonoperating
Amortization of Intangible Assets
Impairment Charge on Reclassified Assets
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Long-term Debt, Gross
Long-term Debt
Current State and Local Tax Expense (Benefit)
Deferred State and Local Income Tax Expense (Benefit)
Effective Income Tax Rate Reconciliation, Other Adjustments, Percent
Deferred Tax Assets, Gross
Deferred Tax Assets, Valuation Allowance
Deferred Tax Assets, Net of Valuation Allowance
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures and Expirations in Period
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Earn-out liabilities, beginning balance
GainLossFromChangeInFairValueOfEarnOutMilestoneLiability
Share-based Compensation Arrangement by Share-based Payment Award, Non-Option Equity Instruments, Outstanding, Number
ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingWeightedAverageExercisePrice
Share-based Compensation Arrangement by Share-based Payment Award, Non-Option Equity Instruments, Exercised
Share-based Compensation Arrangement by Share-based Payment Award, Non-Option Equity Instruments, Forfeitures
Lessee, Operating Lease, Liability, to be Paid, Year One
Lessee, Operating Lease, Liability, to be Paid, Year Two
Lessee, Operating Lease, Liability, to be Paid
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Deferred Revenue