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  <xsd:element id="clsn_ClassOfWarrantOrRightWeightedAverageRemainingContractualTerms" name="ClassOfWarrantOrRightWeightedAverageRemainingContractualTerms" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element id="clsn_ClassOfWarrantsOrRightExercisedDuringPeriod" name="ClassOfWarrantsOrRightExercisedDuringPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
  <xsd:element id="clsn_CommissionOnProceedsFromAtmSharesPercent" name="CommissionOnProceedsFromAtmSharesPercent" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_ConsultantsMember" name="ConsultantsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="clsn_ContractualObligationReductionFortyThreeMonthsFromInitialTerm" name="ContractualObligationReductionFortyThreeMonthsFromInitialTerm" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="clsn_ContractualObligationReductionNineteenMonthsFromInitialTerm" name="ContractualObligationReductionNineteenMonthsFromInitialTerm" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="clsn_ContractualObligationReductionThirtyOneMonthsFromInitialTerm" name="ContractualObligationReductionThirtyOneMonthsFromInitialTerm" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="clsn_ContractualObligationRemaining" name="ContractualObligationRemaining" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="clsn_December2016CommonStockOfferingMember" name="December2016CommonStockOfferingMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="clsn_DeemedDividendRelatedToWarrantModification" name="DeemedDividendRelatedToWarrantModification" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="clsn_DeferredFinanceCharges" name="DeferredFinanceCharges" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="clsn_DeferredRevenueAmortizationPeriod" name="DeferredRevenueAmortizationPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element id="clsn_DefinedContributionPlanEmployerDiscretionaryContributionPercent" name="DefinedContributionPlanEmployerDiscretionaryContributionPercent" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration"/>
  <xsd:element id="clsn_DepositsPolicyTextBlock" name="DepositsPolicyTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_DocumentAndEntityInformation" name="DocumentAndEntityInformation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_EGENIncMember" name="EGENIncMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="clsn_EarnoutMilestoneLiability" name="EarnoutMilestoneLiability" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="clsn_EarnoutMilestoneLiabilityDisclosureTextBlock" name="EarnoutMilestoneLiabilityDisclosureTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="clsn_EstimatedTimeToAchieveTheMilestone" name="EstimatedTimeToAchieveTheMilestone" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_Expires2023Member" name="Expires2023Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_Expires2024Member" name="Expires2024Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_Expires2025Member" name="Expires2025Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_Expires2026Member" name="Expires2026Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_Expires2028Member" name="Expires2028Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_Expires2029Member" name="Expires2029Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_Expires2030Member" name="Expires2030Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_Expires2031Member" name="Expires2031Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_Expires2032Member" name="Expires2032Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_Expires2033Member" name="Expires2033Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_Expires2034Member" name="Expires2034Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_Expires2035Member" name="Expires2035Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_Expires2036Member" name="Expires2036Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_Expires2037Member" name="Expires2037Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_February142017PublicOfferingMember" name="February142017PublicOfferingMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_February2013PreferredStockOfferingMember" name="February2013PreferredStockOfferingMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_FirstFiftyPercentMember" name="FirstFiftyPercentMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="clsn_GainLossFromChangeInFairValueOfEarnOutMilestoneLiability" name="GainLossFromChangeInFairValueOfEarnOutMilestoneLiability" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="clsn_GainLossFromValuationOfEarnoutMilestoneLiability" name="GainLossFromValuationOfEarnoutMilestoneLiability" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_GlioblastomaMultiformeBrainCancerStudyMilestoneMember" name="GlioblastomaMultiformeBrainCancerStudyMilestoneMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_HerculesCreditAgreementMember" name="HerculesCreditAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_HerculesMember" name="HerculesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_HerculesWarrantMember" name="HerculesWarrantMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_HisunMember" name="HisunMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="clsn_IncreaseDecreaseInFairValueOfWarrants" name="IncreaseDecreaseInFairValueOfWarrants" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_IndefiniteLivedInProcessResearchAndDevelopmentMember" name="IndefiniteLivedInProcessResearchAndDevelopmentMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_InvestmentMaturingBetween3And12MonthsMember" name="InvestmentMaturingBetween3And12MonthsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_InvestmentMaturingWithinThreeMonthsMember" name="InvestmentMaturingWithinThreeMonthsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_IssuedToConsultantsForServicesMember" name="IssuedToConsultantsForServicesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_JanuaryTwoThousandFourteenCommonStockOfferingMember" name="JanuaryTwoThousandFourteenCommonStockOfferingMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_July2017DirectOfferingMember" name="July2017DirectOfferingMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_June2016CommonStockOfferingMember" name="June2016CommonStockOfferingMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_LawrencevilleNewJerseyMember" name="LawrencevilleNewJerseyMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="clsn_LicensingTransactionTextBlock" name="LicensingTransactionTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="clsn_LineOfCreditFacilityOriginalLoanFeePercent" name="LineOfCreditFacilityOriginalLoanFeePercent" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="instant"/>
  <xsd:element id="clsn_MaximumBeneficialOwnershipOfThePurchaser" name="MaximumBeneficialOwnershipOfThePurchaser" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_May2015CommonStockOfferingMember" name="May2015CommonStockOfferingMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="clsn_MinimumAgeForEmployeeBenefitPlan" name="MinimumAgeForEmployeeBenefitPlan" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="clsn_NoteToFinancialStatementDetailsTextual" name="NoteToFinancialStatementDetailsTextual" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_NotesToFinancialStatements" name="NotesToFinancialStatements" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_NotesToFinancialStatementsAbstract" name="NotesToFinancialStatementsAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element id="clsn_NumberOfDaysBeforeIssuanceFactoringIntoAverageClosingPrice" name="NumberOfDaysBeforeIssuanceFactoringIntoAverageClosingPrice" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element id="clsn_NumberOfMonthsInWhichFreeRentIsProvided" name="NumberOfMonthsInWhichFreeRentIsProvided" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element id="clsn_NumberOfSharesOfCommonStockIssuableUponExerciseOfWarrantsAndEquityAwards" name="NumberOfSharesOfCommonStockIssuableUponExerciseOfWarrantsAndEquityAwards" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
  <xsd:element id="clsn_NumberOfTrademarkProtectionApplicationPendingForThermoDox" name="NumberOfTrademarkProtectionApplicationPendingForThermoDox" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="clsn_NumberOfWarrantsIssued" name="NumberOfWarrantsIssued" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_October2017UnderwrittenOfferingMember" name="October2017UnderwrittenOfferingMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="clsn_OperatingLeasesMonthlyRentPayment" name="OperatingLeasesMonthlyRentPayment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="clsn_OperatingLeasesMonthlyRentPaymentInFinalYear" name="OperatingLeasesMonthlyRentPaymentInFinalYear" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="clsn_OperatingLeasesMonthlyRentPaymentInFirstYear" name="OperatingLeasesMonthlyRentPaymentInFirstYear" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="clsn_OperatingLossCarryForwardsLimitationOnUse" name="OperatingLossCarryForwardsLimitationOnUse" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_OvarianCancerStudyMilestoneMember" name="OvarianCancerStudyMilestoneMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="clsn_PercentageOfFairMarketValueOfShares" name="PercentageOfFairMarketValueOfShares" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="instant"/>
  <xsd:element id="clsn_PercentageOfOutstandingStockDeterminingFactorForIncentiveStockPrice" name="PercentageOfOutstandingStockDeterminingFactorForIncentiveStockPrice" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="clsn_PreFundedSeriesBBWarrantMember" name="PreFundedSeriesBBWarrantMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_PreFundedSeriesCCCWarrantsMember" name="PreFundedSeriesCCCWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_PremisesLocatedInHuntsvilleAlabamaMember" name="PremisesLocatedInHuntsvilleAlabamaMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="clsn_ProceedsFromIssuanceOfCommonStockAndWarrants" name="ProceedsFromIssuanceOfCommonStockAndWarrants" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="clsn_ProceedsFromIssuanceOfCommonStockGross" name="ProceedsFromIssuanceOfCommonStockGross" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_Range1Member" name="Range1Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_Range2Member" name="Range2Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_Range3Member" name="Range3Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="clsn_RefundOfDepositForLetterOfCredit" name="RefundOfDepositForLetterOfCredit" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_ReverseStockSplitMember" name="ReverseStockSplitMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="clsn_RiskAdjustedAssessmentOfEachMilestone" name="RiskAdjustedAssessmentOfEachMilestone" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="instant"/>
  <xsd:element id="clsn_ScheduleOfChangesInEarnOutMilestoneLiabilitiesTableTextBlock" name="ScheduleOfChangesInEarnOutMilestoneLiabilitiesTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element id="clsn_ScheduleOfWarrantActivityTableTextBlock" name="ScheduleOfWarrantActivityTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_SecondFiftyPercentMember" name="SecondFiftyPercentMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_SeriesAAAWarrantsMember" name="SeriesAAAWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_SeriesAAWarrantMember" name="SeriesAAWarrantMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_SeriesAWarrantMember" name="SeriesAWarrantMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_SeriesBBBWarrantsMember" name="SeriesBBBWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_SeriesBWarrantMember" name="SeriesBWarrantMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_SeriesCWarrantMember" name="SeriesCWarrantMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_SeriesDDDWarrantsMember" name="SeriesDDDWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_SeriesDWarrantMember" name="SeriesDWarrantMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="clsn_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedForfeitureRate" name="SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedForfeitureRate" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration"/>
  <xsd:element id="clsn_ShelfRegistrationStatementAmount" name="ShelfRegistrationStatementAmount" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_ShortTermInvestmentsAvailableForSaleMember" name="ShortTermInvestmentsAvailableForSaleMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_StockIncentivePlan2007Member" name="StockIncentivePlan2007Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="clsn_StockIssuedDuringPeriodSharesExerciseOfWarrants" name="StockIssuedDuringPeriodSharesExerciseOfWarrants" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
  <xsd:element id="clsn_StockIssuedDuringPeriodValueReverseStockSplits" name="StockIssuedDuringPeriodValueReverseStockSplits" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="clsn_TreasuryStockContributedTo401KPlan" name="TreasuryStockContributedTo401KPlan" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_TwoThousandFifteenWarrantsMember" name="TwoThousandFifteenWarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_TwoThousandThirteenWarrants2014WarrantsAndJune2016WarrantsMember" name="TwoThousandThirteenWarrants2014WarrantsAndJune2016WarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="clsn_WarrantsExercisablePeriod" name="WarrantsExercisablePeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element id="clsn_WarrantsIssuedExpirationPeriod" name="WarrantsIssuedExpirationPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element id="clsn_WarrantsTextBlock" name="WarrantsTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_statement-statement-note-11-stockbased-compensation-fair-value-of-option-assumptions-details" name="statement-statement-note-11-stockbased-compensation-fair-value-of-option-assumptions-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_statement-statement-note-11-stockbased-compensation-nonvested-restricted-stock-awards-details" name="statement-statement-note-11-stockbased-compensation-nonvested-restricted-stock-awards-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_statement-statement-note-11-stockbased-compensation-stock-option-activity-details" name="statement-statement-note-11-stockbased-compensation-stock-option-activity-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_statement-statement-note-11-stockbased-compensation-stock-options-outstanding-details" name="statement-statement-note-11-stockbased-compensation-stock-options-outstanding-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_statement-statement-note-11-stockbased-compensation-tables" name="statement-statement-note-11-stockbased-compensation-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_statement-statement-note-12-earnout-milestone-liability-summary-of-the-changes-in-the-earnout-milestone-liability-details" name="statement-statement-note-12-earnout-milestone-liability-summary-of-the-changes-in-the-earnout-milestone-liability-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_statement-statement-note-12-earnout-milestone-liability-tables" name="statement-statement-note-12-earnout-milestone-liability-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_statement-statement-note-13-warrants-summary-of-warrant-activity-details" name="statement-statement-note-13-warrants-summary-of-warrant-activity-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_statement-statement-note-13-warrants-tables" name="statement-statement-note-13-warrants-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_statement-statement-note-17-contingent-liabilities-and-commitments-summary-of-the-future-minimum-payments-required-under-leases-details" name="statement-statement-note-17-contingent-liabilities-and-commitments-summary-of-the-future-minimum-payments-required-under-leases-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_statement-statement-note-17-contingent-liabilities-and-commitments-tables" name="statement-statement-note-17-contingent-liabilities-and-commitments-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_statement-statement-note-3-short-term-investments-available-for-sale-available-for-sale-investment-income-details" name="statement-statement-note-3-short-term-investments-available-for-sale-available-for-sale-investment-income-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_statement-statement-note-3-short-term-investments-available-for-sale-securities-in-a-continuous-unrealized-loss-position-details" name="statement-statement-note-3-short-term-investments-available-for-sale-securities-in-a-continuous-unrealized-loss-position-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_statement-statement-note-3-short-term-investments-available-for-sale-shortterm-investment-by-bond-maturities-details" name="statement-statement-note-3-short-term-investments-available-for-sale-shortterm-investment-by-bond-maturities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_statement-statement-note-3-short-term-investments-available-for-sale-tables" name="statement-statement-note-3-short-term-investments-available-for-sale-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_statement-statement-note-4-fair-values-of-financial-instruments-assets-and-liabilities-at-fair-value-on-a-recurring-basis-details" name="statement-statement-note-4-fair-values-of-financial-instruments-assets-and-liabilities-at-fair-value-on-a-recurring-basis-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_statement-statement-note-4-fair-values-of-financial-instruments-tables" name="statement-statement-note-4-fair-values-of-financial-instruments-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_statement-statement-note-5-acquisition-of-egen-inc-amortization-schedule-for-covenant-not-to-complete-details" name="statement-statement-note-5-acquisition-of-egen-inc-amortization-schedule-for-covenant-not-to-complete-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_statement-statement-note-5-acquisition-of-egen-inc-fair-values-of-acquired-assets-and-liabilities-details" name="statement-statement-note-5-acquisition-of-egen-inc-fair-values-of-acquired-assets-and-liabilities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_statement-statement-note-5-acquisition-of-egen-inc-tables" name="statement-statement-note-5-acquisition-of-egen-inc-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_statement-statement-note-6-property-and-equipment-property-plant-and-equipment-useful-life-details" name="statement-statement-note-6-property-and-equipment-property-plant-and-equipment-useful-life-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_statement-statement-note-6-property-and-equipment-property-plant-and-equipment-useful-life-details-parentheticals" name="statement-statement-note-6-property-and-equipment-property-plant-and-equipment-useful-life-details-parentheticals" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_statement-statement-note-6-property-and-equipment-tables" name="statement-statement-note-6-property-and-equipment-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_statement-statement-note-7-other-accrued-liabilities-other-accrued-liabilities-details" name="statement-statement-note-7-other-accrued-liabilities-other-accrued-liabilities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_statement-statement-note-7-other-accrued-liabilities-tables" name="statement-statement-note-7-other-accrued-liabilities-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_statement-statement-note-9-income-taxes-components-of-the-deferred-tax-asset-details" name="statement-statement-note-9-income-taxes-components-of-the-deferred-tax-asset-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_statement-statement-note-9-income-taxes-operating-loss-carry-forwards-details" name="statement-statement-note-9-income-taxes-operating-loss-carry-forwards-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_statement-statement-note-9-income-taxes-reconciliation-of-the-statutory-tax-rate-to-the-effective-rate-details" name="statement-statement-note-9-income-taxes-reconciliation-of-the-statutory-tax-rate-to-the-effective-rate-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_statement-statement-note-9-income-taxes-tables" name="statement-statement-note-9-income-taxes-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="clsn_statement-statement-significant-accounting-policies-policies" name="statement-statement-significant-accounting-policies-policies" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
</xsd:schema>
