Equity Components [Axis]
Common Stock [Member]
Additional Paid-in Capital [Member]
Treasury Stock [Member]
AOCI Attributable to Parent [Member]
Retained Earnings [Member]
Geographical [Axis]
New Jersey [Member]
Statistical Measurement [Axis]
Maximum [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Horizon Credit Agreement [Member]
Series [Axis]
Horizon Technology Finance Corporation [Member]
SVB Loan Facility [Member]
Variable Rate [Axis]
London Interbank Offered Rate (LIBOR) [Member]
Amendment to Horizon Credit Agreement [Member]
Related Party [Axis]
Silicon Valley Bank [Member]
Prime Rate [Member]
Capital on DemandTM Sales Agreement [Member]
Jones Trading Institutional Services, LLC [Member]
Financial Instrument [Axis]
Commercial Paper [Member]
Government Backed Debt Securities [Member]
Measurement Frequency [Axis]
Fair Value, Recurring [Member]
Corporate Debt Securities [Member]
Fair Value Hierarchy and NAV [Axis]
Fair Value, Inputs, Level 1 [Member]
Fair Value, Inputs, Level 2 [Member]
Fair Value, Inputs, Level 3 [Member]
Fair Value, Nonrecurring [Member]
Inprocess R&D [Member]
Business Acquisition [Axis]
EGEN Inc [Member]
IPR and D Drug Technology Platforms [Member]
Contingent Consideration by Type [Axis]
Ovarian Cancer [Member]
Glioblastoma Multiforme Brain Cancer [Member]
Purchase Agreement [Member]
2018 Aspire Purchase Agreements [Member]
Asset Class [Axis]
IPR and D [Member]
Goodwill [Member]
Finite-Lived Intangible Assets by Major Class [Axis]
Noncompete Agreements [Member]
Initial Horizon Credit Agreement [Member]
Debt Instrument [Axis]
Initial Horizon Credit Agreement Amendment [Member]
Capital on Demand Agreement [Member]
Securities Purchase Agreement [Member]
Original Warrants [Member]
Exchange Agreements [Member]
Warrant [Member]
Underwriting Agreement [Member]
Sale of Stock [Axis]
Underwritten Offering [Member]
January 2021 Registered Direct Offering [Member]
March 2021 Registered Direct Offering [Member]
LPC Purchase Agreement [Member]
Lincoln Park Capital Fund, LLC [Member]
LPC Commitment Shares [Member]
Plan Name [Axis]
2018 Stock Incentive Plan [Member]
Minimum [Member]
2007 Stock Incentive Plan [Member]
Inducement Option Grants [Member]
Title of Individual [Axis]
Five New Employees [Member]
Award Type [Axis]
Restricted Stock [Member]
Equity Stock Awards [Member]
Scenario [Axis]
Granted Under 2018 Plan and 2007 Plan [Member]
2018 Plan [Member]
Inducement Awards [Member]
Share-based Payment Arrangement, Option [Member]
Stock Options and Restricted Stock Awards [Member]
Income Statement Location [Axis]
Research and Development Expense [Member]
General and Administrative Expense [Member]
Amended Asset Purchase Agreement [Member]
Related Party Transaction [Axis]
Within One Year of Achieving Milestone [Member]
10 Business Days of Achieving Milestone [Member]
EGWC, Inc [Member]
Fair Value Earnout Milestone Liability [Member]
1st Lease Amendment [Member]
First Year [Member]
Final Year [Member]
2nd Lease Amendment [Member]
EGEN Asset Purchase Agreement [Member]
Huntsville Alabama [Member]
Accounting Standards Update [Axis]
Accounting Standards Update 2016-02 [Member]
Accounting Standards Update 2021-01 [Member]
Operating Leases [Member]
Legal Entity of Counterparty, Type [Axis]
Hisun [Member]
Cover [Abstract]
Document Type
Amendment Flag
Amendment Description
Document Registration Statement
Document Annual Report
Document Quarterly Report
Document Transition Report
Document Shell Company Report
Document Shell Company Event Date
Document Period Start Date
Document Period End Date
Document Fiscal Period Focus
Document Fiscal Year Focus
Current Fiscal Year End Date
Entity File Number
Entity Registrant Name
Entity Central Index Key
Entity Primary SIC Number
Entity Tax Identification Number
Entity Incorporation, State or Country Code
Entity Address, Address Line One
Entity Address, Address Line Two
Entity Address, Address Line Three
Entity Address, City or Town
Entity Address, State or Province
Entity Address, Country
Entity Address, Postal Zip Code
Country Region
City Area Code
Local Phone Number
Extension
Written Communications
Soliciting Material
Pre-commencement Tender Offer
Pre-commencement Issuer Tender Offer
Title of 12(b) Security
No Trading Symbol Flag
Trading Symbol
Security Exchange Name
Title of 12(g) Security
Security Reporting Obligation
Annual Information Form
Audited Annual Financial Statements
Entity Well-known Seasoned Issuer
Entity Voluntary Filers
Entity Current Reporting Status
Entity Interactive Data Current
Entity Filer Category
Entity Small Business
Entity Emerging Growth Company
Elected Not To Use the Extended Transition Period
Document Accounting Standard
Other Reporting Standard Item Number
Entity Shell Company
Entity Public Float
Entity Bankruptcy Proceedings, Reporting Current
Entity Common Stock, Shares Outstanding
Documents Incorporated by Reference [Text Block]
Statement of Financial Position [Abstract]
ASSETS
Current assets:
Cash and cash equivalents
Investment in debt securities - available for sale, at fair value
Accrued interest on investment in debt securities
Advances and deposits on clinical programs and other current assets
Total current assets
Property and equipment (at cost, less accumulated depreciation and amortization)
Other assets:
Money market investments, restricted cash
Deferred income tax asset
In-process research and development, net
Goodwill
Operating lease right-of-use assets, net
Other intangible assets, net
Deposits and other assets
Total other assets
Total assets
LIABILITIES AND STOCKHOLDERS’ EQUITY
Current liabilities:
Accounts payable – trade
Other accrued liabilities
Notes payable – current portion, net of deferred financing costs
Operating lease liability - current portion
Deferred revenue - current portion
Total current liabilities
Earn-out milestone liability
Notes payable – non-current portion, net of deferred financing costs
Operating lease liability - non-current portion
Deferred revenue - non-current portion
Total liabilities
Commitments and contingencies
Stockholders’ equity:
Preferred Stock - $0.01 par value (100,000 shares authorized, and no shares issued or outstanding at September 30, 2021 and December 31, 2020)
Common stock - $0.01 par value (112,500,000 shares authorized; 86,558,070 and 40,701,356 shares issued at September 30, 2021 and December 31, 2020, respectively, and 86,557,736 and 40,701,022 shares outstanding at September 30, 2021 and December 31, 2020, respectively)
Additional paid-in capital
Accumulated other comprehensive loss
Accumulated deficit
Total stockholders’ equity before treasury stock
Treasury stock, at cost (334 shares at September 30, 2021 and December 31, 2020)
Total stockholders’ equity
Total liabilities and stockholders’ equity
Preferred stock, par value
Preferred stock, shares authorized
Preferred stock, shares issued
Preferred stock, shares outstanding
Common stock, par value
Common stock, shares authorized
Common stock, shares issued
Common stock, shares outstanding
Treasury stock, shares
Income Statement [Abstract]
Licensing revenue
Operating expenses:
Research and development
General and administrative
Total operating expenses
Loss from operations
Other (expense) income:
Loss from change in fair-value of earn-out milestone liability
Impairment of in-process research and development
Investment income
Interest expense
Recognized loss on extinguishment of debt
Other (expense) income
Total other (expense) income, net
Net loss
Net loss per common share
Basic and diluted
Weighted average shares outstanding
Basic and diluted
Statement of Comprehensive Income [Abstract]
Other comprehensive (loss) gain
Changes in:
Realized (gains) losses on debt securities recognized in investment income, net
Unrealized (losses) gains on debt securities, net
Change in unrealized (losses) gains on available for sale securities, net
Net loss
Comprehensive loss
Statement of Cash Flows [Abstract]
Cash flows from operating activities:
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization
Change in fair value of earn-out milestone liability
Recognition of deferred revenue
Stock-based compensation costs
Deferred income tax asset
Impairment of in-process research and development
Amortization of deferred finance charges and debt discount associated with notes payable
Fair value of warrants issued in exchange for services
Net changes in:
Accrued interest on investment securities
Advances, deposits, and other current assets
Accounts payable and accrued liabilities
Net cash used in operating activities
Cash flows from investing activities:
Purchases of investment securities
Proceeds from sale and maturity of investment securities
Purchases of property and equipment
Net cash (used in) provided by investing activities
Cash flows from financing activities:
Proceeds from sale of common stock equity, net of issuance costs
Proceeds from issuance of common stock upon conversion of stock warrants
Proceeds from issuance of common stock upon conversion of stock options
Proceeds from the SVB Loan Facility, net of issuance costs
Payoff of the Horizon Credit Agreement and accrued end of term fees
Proceeds from Payroll Protection Program (PPP) loans
Repayments on Payroll Protection Program (PPP) loans
Net cash provided by financing activities
Change in cash, cash equivalents and restricted cash
Cash, cash equivalents and restricted cash at beginning of period
Cash, cash equivalents and restricted cash at end of period
Supplemental disclosures of cash flow information:
Interest paid
Cash paid for amounts included in measurement of lease liabilities:
Operating cash flows from lease payments
Common stock issued to settle accrued bonuses
Fair value of warrants issued in connection with debt facility, net of cancelled warrants
Realized and unrealized gains (losses), net, on investment securities
Statement [Table]
Statement [Line Items]
Beginning balance, value
Beginning balance, shares
Sale of equity through equity financing facilities
Sale of equity through equity financing facilities, shares
Shares issued upon exercise of common stock warrants, net of fees
Shares issued upon exercise of common stock warrants, net of fees
Shares issued upon exercise of options to purchase common stock
Shares issued upon exercise of options to purchase common stock, shares
Issuance of common stock upon exercise of options
Issuance of common stock upon exercise of options, shares
Common stock warrants issued in exchange for services
Issuance of restricted stock
Issuance of restricted stock, shares
Realized and unrealized gains and losses, net, on investments securities
Stock-based compensation expense
Common stock issued to settle accrued bonuses
Common stock issued to settle accrued bonuses
Ending balance, value
Ending balance, shares
Accounting Policies [Abstract]
Business Description
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Basis of Presentation
Financial Condition and Business Plan
Accounting Changes and Error Corrections [Abstract]
New Accounting Pronouncements
Receivables [Abstract]
Restricted Cash
Earnings Per Share [Abstract]
Net Loss per Common Share
Investments, Debt and Equity Securities [Abstract]
Investment in Debt Securities-Available for Sale
Fair Value Measurements
Fair Value Measurements
Goodwill and Intangible Assets Disclosure [Abstract]
Intangible Assets
Payables and Accruals [Abstract]
Accrued Liabilities
Debt Disclosure [Abstract]
Notes Payable
Equity [Abstract]
Stockholders’ Equity
Share-based Payment Arrangement [Abstract]
Stock-Based Compensation
Earn-out Milestone Liability
Earn-Out Milestone Liability
Warrants
Warrants
Leases
Leases
Technology Development And Licensing Agreements
Technology Development and Licensing Agreements
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies
Schedule of Cash and Cash Equivalents and Restricted Cash
Schedule of Cost, Fair Value and Maturities of Short Term Investments
Summary of Investment Securities Gross Unrealized Gains (Losses)
Summary of Net Realized Losses on Sales of Available for Sale Securities and Investment Income Interest and Dividends
Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis
Schedule of Fair Value of Assets Acquired
Schedule of Accrued Liabilities
Schedule of Future Principle Payments, Net of Unamortized Debt Discounts
Schedule of Debt
Summary of Stock Option Awards and Restricted Stock Grants
Schedule of Assumptions Used to Determine Fair Value of Options Granted
Schedule of Changes in Earn-out Milestone Liability
Schedule of Risk Adjustment Assessment
Summary of Warrant Activity
Schedule of Lease Payments and Maturity of Operating Lease Liabilities
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Cumulative net losses
Cash and cash equivalents, restricted cash, short-term investments, interest receivable
Net proceeds from sale of net operating losses
Receivable on sale of net operating losses
Proceeds from Contributed Capital
Debt Instrument, Description
Debt Instrument, Interest Rate, Stated Percentage
Repayments of Notes Payable
Debt Instrument, Face Amount
Debt instrument related end term charges
Line of Credit Facility, Maximum Borrowing Capacity
Repayment of outstanding in-debtedness amount
Line of Credit Facility, Remaining Borrowing Capacity
Proceeds from Warrant Exercises
Money market investments, restricted
Total
Schedule of Defined Benefit Plans Disclosures [Table]
Defined Benefit Plan Disclosure [Line Items]
Line of Credit Facility, Description
Restricted Investments
Shares of common stock issuable upon exercise of warrants and equity awards
Class of Warrant or Right, Exercise Price of Warrants or Rights
Number of shares of common stock issued in calculation basic loss per share
Marketable Securities [Table]
Marketable Securities [Line Items]
Short-term investment maturities - Between 3-12 months, cost
Short-term investment maturities - Between 3-12 months, fair value
Short-term investment maturities - Within 3 months, cost
Short-term investment maturities - Within 3 months, fair value
Short-term investment maturities - Between 3-12 months, cost
Short-term investment maturities - Between 3-12 months, fair value
Total, cost
Total, fair value
Investments with unrealized gains, Fair Value
Investments with unrealized gains, Unrealized Holding Gains (Losses)
Investments with unrealized losses, Fair Value
Investments with unrealized Losses, Unrealized Holding Gains (Losses)
Investment securities, available for sale
Investments with unrealized Gains (Losses), Unrealized Holding Gains (Losses)
Interest and dividends accrued and paid
Realized (losses) gains
Investment income, net
Fair Value, Recurring and Nonrecurring [Table]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Schedule of Finite-Lived Intangible Assets [Table]
Finite-Lived Intangible Assets [Line Items]
Intangible assets, beginning balance
Amortization
Intangible assets, ending balance
Schedule of Restructuring and Related Costs [Table]
Restructuring Cost and Reserve [Line Items]
Indefinite-lived Intangible Assets Acquired
Finite-lived Intangible Assets Acquired
Asset Impairment Charges
Noncash Charge
Finite-Lived Intangible Asset, Useful Life
Amortization
Finite-Lived Intangible Assets, Net
Finite-Lived Intangible Assets, Accumulated Amortization
Goodwill, Acquired During Period
Amounts due to contract research organizations and other contractual agreements
Accrued payroll and related benefits
Accrued professional fees
Accrued interest
Other
Total
2022
2023
2024
2025 and thereafter
Subtotal of future principal payments
Unamortized debt premium, net
Total
Principal balance at June 18, 2021
Early termination fees
End of term charges
Total
Schedule of Short-term Debt [Table]
Short-term Debt [Line Items]
Proceeds from Lines of Credit
Restricted cash
Final payment percentage
Long-term Line of Credit
Interest and Debt Expense
End of term charge percentage
Amortization of Debt Issuance Costs
Interest Expense, Debt
Amortization of Debt Issuance Costs and Discounts
Debt instrument face amount
Debt Instrument, Interest Rate Terms
Payment for Debt Extinguishment or Debt Prepayment Cost
Debt Instrument, Fee Amount
Debt Instrument, Restrictive Covenants
Loan Processing Fee
Debt Instrument, Unamortized Discount
Debt Issuance Costs, Net
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Fair Value Adjustment of Warrants
Class of Warrant or Right, Outstanding
Warrants cancelled
Warrants Not Settleable in Cash, Fair Value Disclosure
End of term fees
Gain (Loss) on Contract Termination
Accumulated Other Comprehensive Income (Loss) [Table]
Accumulated Other Comprehensive Income (Loss) [Line Items]
Shelf registration statement amount
Less than 12 months, unrealized gains, fair value
Stock Issued During Period, Shares, New Issues
Proceeds from Issuance of Common Stock
Shares Issued, Price Per Share
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right
Warrants and Rights Outstanding, Term
Proceeds from Issuance of Warrants
Share Price
[custom:UnderwritingDiscountPricePerShare]
Payments from sale of nols
Placement agent fee description.
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number Outstanding, Outstanding, Beginning balance
Weighted Average Exercise Price, Outstanding, Beginning balance
Number Outstanding, Non-vested stock awards, Outstanding, Beginning balance
Weighted Average Grant Date Fair Value, Non-vested stock awards, Outstanding, Beginning balance
Number Outstanding, Options granted
Weighted Average Exercise Price, Options granted
Number Outstanding, Non-vested stock awards, Granted
Weighted Average Grant Date Fair Value, Non-vested stock awards, Granted
Number Outstanding, Options exercised or vested and issued
Weighted Average Exercise Price, Options exercised or vested and issued
Number Outstanding, Non-vested stock awards, exercised or vested and issued
Weighted Average Grant Date Fair Value, Non-vested stock awards, exercised or vested and issued
Number Outstanding, Options canceled or expired
Weighted Average Exercise Price, Options canceled or expired
Number Outstanding, Non-vested stock awards, Forfeited
Weighted Average Grant Date Fair Value, Non-vested stock awards, Forfeited
Number Outstanding, Outstanding, Ending balance
Weighted Average Exercise Price, Outstanding, Ending balance
Number Outstanding, Non-vested stock awards, Outstanding, Ending balance
Weighted Average Grant Date Fair Value, Non-vested stock awards, Outstanding, Ending balance
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Aggregate Intrinsic Value, Outstanding, Ending balance
Aggregate Intrinsic Value, Non-vested stock awards, Outstanding, Ending balance
Number Outstanding, Exercisable, Ending balance
Weighted Average Exercise Price, Exercisable, Ending balance
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Aggregate Intrinsic Value, Exercisable, Ending balance
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Minimum
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Maximum
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Minimum
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Maximum
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term
Expected dividend yield
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant
Stock options, strike price description
Shares, Issued
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period
Common Stock, Capital Shares Reserved for Future Issuance
Share-based Payment Arrangement, Expense
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Schedule Of Changes In Earn-out Milestone Liability
Earn-out liabilities, beginning balance
Non-cash gain loss from the adjustment for the change in fair value
Earn-out liabilities, ending balance
Risk-adjustment Assessment of achieving each Milestone
Discount Rate
Estimated time to achieve mile stone
Earnout milestone liability
Business Combination, Consideration Transferred, Liabilities Incurred
Non-cash charge on earnout milestone liability
Earnout payment options description
Summary Of Warrant Activity
Number of Warrants Issued, Warrants outstanding, Beginning balance
Weighted Average Exercise Price, Warrants outstanding, Beginning balance
Number of Warrants Issued, Warrants exercised
Weighted Average Exercise Price, Warrants exercised
Number of Warrants Issued, Warrants outstanding, Ending balance
Weighted Average Exercise Price, Warrants outstanding, Ending balance
Aggregate intrinsic value of outstanding warrants
Weighted average remaining contractual terms (years)
Schedule Of Lease Payments And Maturity Of Operating Lease Liabilities
Remainder of 2021
2022
2023
2024 and thereafter
Subtotal future lease payments
Less imputed interest
Total lease liabilities
Operating Lease, Weighted Average Remaining Lease Term
Operating Lease, Weighted Average Discount Rate, Percent
Lessee, Operating Lease, Description
Area of Land
Lessee, Operating Lease, Term of Contract
Lease Expiration Date
Payments for Rent
Operating Lease, Right-of-Use Asset
Operating Lease, Liability
Other Liabilities
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Operating Lease, Cost
Operating Lease, Payments
Schedule of Accounts, Notes, Loans and Financing Receivable [Table]
Accounts, Notes, Loans and Financing Receivable [Line Items]
Proceeds from License Fees Received
Deferred Revenue
Deferred revenue amortization period
Upfront payment being recognized
Litigation Settlement, Expense
Payments for Legal Settlements
Investment income loss non operating.
Recognized gains losses on extinguishment of debt non operating.
Gain (loss) from change in valuation of earn-out milestone liability.
Impairment of in-process research and development.
Amortization of deferred finance charges and debt discount associated with note payable.
Proceeds from issuance of common stock upon conversion of stock warrants.
Realizedand unrealized gains and losses net on investment in debt securities.
Fair value of warrants issued in exchange for services.
Proceeds from issuance of common stock upon conversion of stock options.
Shares issued upon exercise of common stock warrants, net of fees.
Issuance of common stock upon exercise of options.
Adjustments to additional paid in capitaCommon stock warrants issued in exchange for services
Stock issued upon exercise of common stock warrants shares.
Issuance of common stock upon exercise of options shares.
Cash and cash equivalents, restricted cash short-term investments and receivable on sale of net operating losses.
Net proceeds from sale of net operating losses.
New Jersey [Member]
Receivable on sale of net operating losses.
Horizon Credit Agreement [Member]
Horizon Technology Finance Corporation [Member]
Amendment to Horizon Credit Agreement [Member]
Debt instrument related end term charges.
Silicon Valley Bank [Member]
SVB Loan Facility [Member]
Repayment of outstanding indebtedness amount.
Capital on DemandTM Sales Agreement [Member]
Jones Trading Institutional Services, LLC [Member]
Represents the total number of Shares of common stock issuable upon exercise of warrants and equity awards.
Number of shares of common stock issued in calculation basic loss per share.
Government Backed Debt Securities [Member]
Amortized cost of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale) with single maturity date and allocated without single maturity date, maturing in next rolling three months.
Amortized cost of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale), with single maturity date and allocated without single maturity date, maturing in next rolling three to twelve months.
The current amount of amortized cost of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).
Fair value of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale), with single maturity date and allocated without single maturity date, maturing in next rolling three months.
Fair value of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale), with single maturity date and allocated without single maturity date, maturing in next rolling three to twelve months.
Available for sale securities unrealized gains fair value.
Available for sale securities unrealized losses fair value.
Available for sale securities unrealized gains less than twelve months.
Available for sale securities unrealized losses less than twelve months.
Available for sale securities unrealized gains (losses) less than twelve months.
Inprocess R&D [Member]
Information pertaining to the business acquisition of EGEN, Inc.
IPR and D Drug Technology Platforms [Member]
Ovarian Cancer [Member]
Glioblastoma Multiforme Brain Cancer [Member]
Non-cash charge.
Purchase Agreement [Member]
2018 Aspire Purchase Agreements [Member]
IPR and D [Member]
Final Payment Percentage.
End of term charge percentage.
Long-term debt maturities repayments of principal year four and there-after.
Initial Horizon Credit Agreement [Member]
Warrants cancelled.
End of term fees.
Initial Horizon Credit Agreement Amendment [Member]
Shelf Registration statement amount.
Aggregate offering price.
Capital on Demand Agreement [Member]
Securities Purchase Agreement [Member]
Original Warrants [Member]
Exchange Agreements [Member]
Underwriting Agreement [Member]
Underwritten Offering [Member]
Underwriting discount price per share.
Percentage of underwriting discount on public offering price.
January 2021 Registered Direct Offering [Member]
Placement agent fee description.
March 2021 Registered Direct Offering [Member]
LPC Purchase Agreement [Member]
Lincoln Park Capital Fund, LLC [Member]
LPC Commitment Shares [Member]
2018 Stock Incentive Plan [Member]
Stock options, strike price description.
2007 Stock Incentive Plan [Member]
Inducement Option Grants [Member]
Five New Employees [Member]
Equity Stock Awards [Member]
Granted Under 2018 Plan and 2007 Plan [Member]
2018 Plan [Member]
Inducement Awards [Member]
Stock Options and Restricted Stock Awards [Member]
Summary of Stock Option and Restricted Stock Awards [Table Text Block]
Earnout Milestone Liability Disclosure [Text Block]
The amount of gain (loss) from the change in the fair value of earn-out milestone liability.
Earn-out liabilities, beginning balance.
Earnout milestone liability.
Amended Asset Purchase Agreement [Member]
Within One Year of Achieving Milestone [Member]
10 Business Days of Achieving Milestone [Member]
EGWC, Inc [Member]
Fair Value Earnout Milestone Liability [Member]
Non-cash charge on earnout milestone liability.
Earn-out payment options, description.
Schedule of Changes in Earn Out Milestone Liabilities [Table Text Block]
Schedule of Risk Adjustment Assessment [Table Text Block]
Risk-adjustment Assessment of achieving each Milestone.
Discount rate on milestone liabilities.
Estimated time to achieve milestone liability.
Warrants [Text Block]
Weighted average price at which grantees can acquire the shares reserved for issuance under the stock non-option equity plan.
Share based compensation arrangement by share based payment award non option equity instruments exercised in period weighted average exercise price.
Sharebased compensation arrangement by sharebased payment award non options outstanding intrinsic value.
Weighted average remaining contractual term for non-option awards outstanding, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.
1st Lease Amendment [Member]
First Year [Member]
Final Year [Member]
2nd Lease Amendment [Member]
EGEN Asset Purchase Agreement [Member]
Huntsville Alabama [Member]
Operating Leases [Member]
Lessee, operating lease, liability, to be paid, year four and there after.
Operating lease imputed interest.
Licensing Transaction [Text Block]
Hisun [Member]
The amortization period for deferred revenue.
Upfront Payment, being recognized.
Fair value of warrants issued in connection with debt facility net of cancelled warrants.
Early termination fee.
End of term charge.
Assets, Current
Other Assets, Noncurrent
Assets
Liabilities, Current
Liabilities
Stockholders' Equity before Treasury Stock
Treasury Stock, Value
Stockholders' Equity Attributable to Parent
Liabilities and Equity
Operating Expenses
Operating Income (Loss)
Nonoperating Income (Expense)
Weighted Average Number of Shares Outstanding, Basic and Diluted
Other Comprehensive Income (Loss), Reclassification Adjustment from AOCI for Sale of Securities, Net of Tax
OCI, Debt Securities, Available-for-Sale, Gain (Loss), after Adjustment and Tax
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Contract with Customer, Liability, Revenue Recognized
Deferred Income Tax Expense (Benefit)
Increase (Decrease) in Accrued Investment Income Receivable
Increase (Decrease) in Prepaid Expense and Other Assets
Net Cash Provided by (Used in) Operating Activities
Payments to Acquire Debt Securities, Available-for-sale
Payments to Acquire Property, Plant, and Equipment
Net Cash Provided by (Used in) Investing Activities
Repayments of Long-term Debt
Repayments of Debt
Net Cash Provided by (Used in) Financing Activities
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations
Interest Paid, Excluding Capitalized Interest, Operating Activities
Shares, Outstanding
StockIssuedUponExerciseOfCommonStockWarrantsShares
Stock Issued During Period, Value, Other
Stock Issued During Period, Shares, Other
Derivatives and Fair Value [Text Block]
WarrantsTextBlock
Lessee, Operating Leases [Text Block]
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents
Short-term investment maturities - Between 3-12 months, cost [Default Label]
Amortization [Default Label]
Long-term Debt, Gross
Long-term Debt
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures and Expirations in Period
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Earn-out liabilities, beginning balance
Share-based Compensation Arrangement by Share-based Payment Award, Non-Option Equity Instruments, Outstanding, Number
ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingWeightedAverageExercisePrice
Share-based Compensation Arrangement by Share-based Payment Award, Non-Option Equity Instruments, Exercised
Lessee, Operating Lease, Liability, to be Paid, Year Two
Lessee, Operating Lease, Liability, to be Paid, Year Three
Lessee, Operating Lease, Liability, to be Paid
Lessee, Operating Lease, Liability, Undiscounted Excess Amount