000 - Document - Document And Entity Information link:calculationLink link:definitionLink link:presentationLink 001 - Statement - Condensed Consolidated Balance Sheets (Current Period Unaudited) link:calculationLink link:definitionLink link:presentationLink 002 - Statement - Condensed Consolidated Balance Sheets (Current Period Unaudited) (Parentheticals) link:calculationLink link:definitionLink link:presentationLink 003 - Statement - Condensed Consolidated Statements of Operations (Unaudited) link:calculationLink link:definitionLink link:presentationLink 004 - Statement - Condensed Consolidated Statements of Comprehensive Loss (Unaudited) link:calculationLink link:definitionLink link:presentationLink 005 - Statement - Condensed Consolidated Statements of Cash Flows (Unaudited) link:calculationLink link:definitionLink link:presentationLink 006 - Disclosure - Note 1 - Business Description link:calculationLink link:definitionLink link:presentationLink 007 - Disclosure - Note 2 - Basis of Presentation link:calculationLink link:definitionLink link:presentationLink 008 - Disclosure - Note 3 - Management's Plan link:calculationLink link:definitionLink link:presentationLink 009 - Disclosure - Note 4 - New Accounting Pronouncements link:calculationLink link:definitionLink link:presentationLink 010 - Disclosure - Note 5 - Net Loss Per Common Share link:calculationLink link:definitionLink link:presentationLink 011 - Disclosure - Note 6 - Investment Securities - Available for Sale link:calculationLink link:definitionLink link:presentationLink 012 - Disclosure - Note 7 - Fair Value of Measurements link:calculationLink link:definitionLink link:presentationLink 013 - Disclosure - Note 8 - Acquisition of EGEN, Inc. link:calculationLink link:definitionLink link:presentationLink 014 - Disclosure - Note 9 - Accrued Liabilities link:calculationLink link:definitionLink link:presentationLink 015 - Disclosure - Note 10 - Note Payable link:calculationLink link:definitionLink link:presentationLink 016 - Disclosure - Note 11 - Stockholders' Equity link:calculationLink link:definitionLink link:presentationLink 017 - Disclosure - Note 12 - Stock Based Compensation link:calculationLink link:definitionLink link:presentationLink 018 - Disclosure - Note 13 - Earn-out Milestone Liability link:calculationLink link:definitionLink link:presentationLink 019 - Document - Note 14 - Warrants link:calculationLink link:definitionLink link:presentationLink 020 - Disclosure - Note 15 - Contingent Liabilities and Commitments link:calculationLink link:definitionLink link:presentationLink 021 - Disclosure - Note 16 - Technology Development and Licensing Agreements link:calculationLink link:definitionLink link:presentationLink 022 - Disclosure - Note 6 - Investment Securities - Available for Sale (Tables) link:calculationLink link:definitionLink link:presentationLink 023 - Disclosure - Note 7 - Fair Value of Measurements (Tables) link:calculationLink link:definitionLink link:presentationLink 024 - Disclosure - Note 8 - Acquisition of EGEN, Inc. (Tables) link:calculationLink link:definitionLink link:presentationLink 025 - Disclosure - Note 9 - Accrued Liabilities (Tables) link:calculationLink link:definitionLink link:presentationLink 026 - Disclosure - Note 10 - Note Payable (Tables) link:calculationLink link:definitionLink link:presentationLink 027 - Disclosure - Note 12 - Stock Based Compensation (Tables) link:calculationLink link:definitionLink link:presentationLink 028 - Disclosure - Note 13 - Earn-out Milestone Liability (Tables) link:calculationLink link:definitionLink link:presentationLink 029 - Disclosure - Note 14 - Warrants (Tables) link:calculationLink link:definitionLink link:presentationLink 030 - Disclosure - Note 3 - Management's Plan (Details Textual) link:calculationLink link:definitionLink link:presentationLink 031 - Disclosure - Note 4 - New Accounting Pronouncements (Details Textual) link:calculationLink link:definitionLink link:presentationLink 032 - Disclosure - Note 5 - Net Loss Per Common Share (Details Textual) link:calculationLink link:definitionLink link:presentationLink 033 - Disclosure - Note 6 - Investment Securities - Available for Sale (Details Textual) link:calculationLink link:definitionLink link:presentationLink 034 - Disclosure - Note 6 - Short-term Investment by Bond Maturities (Details) link:calculationLink link:definitionLink link:presentationLink 035 - Disclosure - Note 6 - Investment Income (Details) link:calculationLink link:definitionLink link:presentationLink 036 - Disclosure - Note 6 - Investment Securities Gross Unrealized Losses and Fair Value by Investment Category (Details) link:calculationLink link:definitionLink link:presentationLink 037 - Disclosure - Note 6 - Component of Accumulated Other Comprehensive Loss (Details) link:calculationLink link:definitionLink link:presentationLink 038 - Disclosure - Note 7 - Assets and Liabilities at Fair Value on a Recurring Basis (Details) link:calculationLink link:definitionLink link:presentationLink 039 - Disclosure - Note 8 - Acquisition of EGEN, Inc. (Details Textual) link:calculationLink link:definitionLink link:presentationLink 040 - Disclosure - Note 8 - Fair Value of Consideration (Details) link:calculationLink link:definitionLink link:presentationLink 041 - Disclosure - Note 8 - Fair Value of Consideration (Details) (Parentheticals) link:calculationLink link:definitionLink link:presentationLink 042 - Disclosure - Note 8 - Summary of Estimated Fair Values of Acquired Assets and Liabilities (Details) link:calculationLink link:definitionLink link:presentationLink 043 - Disclosure - Note 9 - Accrued Liabilities (Details) link:calculationLink link:definitionLink link:presentationLink 044 - Disclosure - Note 10 - Note Payable (Details Textual) link:calculationLink link:definitionLink link:presentationLink 045 - Disclosure - Note 10 - Notes Payable with Hercules Credit Agreement (Details) link:calculationLink link:definitionLink link:presentationLink 046 - Disclosure - Note 10 - Future Principal Payments Due on the Credit Agreement (Details) link:calculationLink link:definitionLink link:presentationLink 047 - Disclosure - Note 11 - Stockholders' Equity (Details Textual) link:calculationLink link:definitionLink link:presentationLink 048 - Disclosure - Note 12 - Stock Based Compensation (Details Textual) link:calculationLink link:definitionLink link:presentationLink 049 - Disclosure - Note 12 - Stock Option and Restricted Stock Awards (Details) link:calculationLink link:definitionLink link:presentationLink 050 - Disclosure - Note 12 - Fair Value of Option Assumptions (Details) link:calculationLink link:definitionLink link:presentationLink 051 - Disclosure - Note 13 - Earn-out Milestone Liability (Details Textual) link:calculationLink link:definitionLink link:presentationLink 052 - Disclosure - Note 13 - Schedule of Milestone Risk-Adjustment Assessment (Details) link:calculationLink link:definitionLink link:presentationLink 053 - Disclosure - Note 13 - Summary of the Changes in the Earn-out Milestone Liability (Details) link:calculationLink link:definitionLink link:presentationLink 054 - Disclosure - Note 14 - Summary of Warrant Activity (Details) link:calculationLink link:definitionLink link:presentationLink 055 - Disclosure - Note 15 - Contingent Liabilities and Commitments (Details Textual) link:calculationLink link:definitionLink link:presentationLink 056 - Disclosure - Note 16 - Technology Development and Licensing Agreements (Details Textual) link:calculationLink link:definitionLink link:presentationLink