Statement of Financial Position [Abstract] ASSETS ASSETS [Abstract] Current assets: Current assets: [Abstract] Cash and cash equivalents Investment securities – available for sale, at fair value Accrued interest receivable on investment securities Advances, deposits and other current assets Total current assets Property and equipment (at cost, less accumulated depreciation of $1,349,690 and $1,264,190, respectively) Other assets: Other assets: [Abstract] Deposits, deferred fees and other assets Patent licensing fees, net Total other assets Total assets LIABILITIES AND STOCKHOLDERS' EQUITY LIABILITIES AND STOCKHOLDERS' EQUITY [Abstract] Current liabilities: Current liabilities: [Abstract] Accounts payable Accrued liabilities Notes payable - current portion Deferred revenue - current portion Total current liabilities Carrying value as of the balance sheet date of common stock warrant liability. Common stock warrant liability Notes payable – non-current portion Deferred revenue - non-current portion Other non-current liabilities Total liabilities Stockholders' equity: Stockholders' equity: [Abstract] Common stock, $0.01 par value; 75,000,000 shares authorized; 17,347,665 and 13,737,970 shares issued at March 31, 2014 and December 31, 2013, and 17,217,066 and 13,604,975 shares outstanding at March 31, 2014 and December 31, 2013, respectively Additional paid-in capital Accumulated other comprehensive loss Accumulated deficit Subtotal Treasury stock, at cost (130,599 and 132,995 shares at March 31, 2014 and December 31, 2013, respectively) Total stockholders' equity Total liabilities and stockholders' equity Accumulated Depreciation (in Dollars) Preferred stock, par value (in Dollars per share) Preferred stock, shares authorized Preferred stock, shares issued Preferred stock, shares outstanding Common stock, par value (in Dollars per share) Common stock, shares authorized Common stock, shares issued Common stock, shares outstanding Treasury stock, shares Income Statement [Abstract] Scenario, Unspecified [Domain] Licensing revenue Operating expenses: Operating expenses: [Abstract] Research and development General and administrative Total operating expenses Loss from operations Non-cash deemed dividend from beneficial conversion feature on convertible preferred stock Other income (expense): Other income (expense): [Abstract] The amount recognized in earnings related to the change in fair value during the period of common stock warrant liability. Gain from change in valuation of common stock warrant liability Investment income, net Interest expense Total other (expense) income, net Net loss attributable to common shareholders Net loss attributable to common shareholders per common share – basic and diluted (in Dollars per share) Weighted average shares outstanding – basic and diluted (in Shares) Statement of Comprehensive Income [Abstract] Net loss Changes in: Changes in: [Abstract] Realized loss on investment securities recognized in investment income, net Unrealized loss on investment securities Other comprehensive gain (loss) Total comprehensive loss Statement of Cash Flows [Abstract] Major Types of Debt and Equity Securities [Domain] Cash flows from operating activities: Cash flows from operating activities: [Abstract] Non-cash items included in net loss: Non-cash items included in net loss: [Abstract] Depreciation and amortization The non-cash amount recognized in earnings related to the change in fair value during the period of common stock warrant liability. Change in fair value of common stock warrant liability Deferred revenue Stock-based compensation Treasury shares issued for services and 401(k) matching contribution Change in deferred rent liability Deferred finance charges. Deferred finance charges Net changes in: Net changes in: [Abstract] Deposits, advances, other current assets and other assets Accounts payable Accrued liabilities Cash received for non-refundable research and development fee. Cash received for non-refundable research and development fee Net cash (used in) provided by operating activities: Cash flows from investing activities: Cash flows from investing activities: [Abstract] Purchases of investment securities Proceeds from sale and maturity of investment securities Net cash used in investing activities Cash flows from financing activities: Cash flows from financing activities: [Abstract] Proceeds from sale of common stock equity, net of issuance costs Proceeds from sale of preferred stock, net of issuance costs Proceeds from exercise of common stock warrants Proceeds from exercise of options to purchase common stock Principal payments on notes payable Net cash provided by financing activities Decrease in cash and cash equivalents Cash and cash equivalents at beginning of period Cash and cash equivalents at end of period Supplemental disclosures of cash flow information: Supplemental disclosures of cash flow information: [Abstract] Interest paid Disclosure Text Block [Abstract] Nature of Operations [Text Block] Basis of Presentation and Significant Accounting Policies [Text Block] Description of New Accounting Pronouncements Not yet Adopted [Text Block] Earnings Per Share [Abstract] Earnings Per Share [Text Block] Investments, Debt and Equity Securities [Abstract] Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block] Fair Value Disclosures [Abstract] Fair Value Disclosures [Text Block] Payables and Accruals [Abstract] Accounts Payable and Accrued Liabilities Disclosure [Text Block] Debt Disclosure [Abstract] Debt Disclosure [Text Block] Stockholders' Equity Note [Abstract] Stockholders' Equity Note Disclosure [Text Block] Disclosure of Compensation Related Costs, Share-based Payments [Abstract] Disclosure of Compensation Related Costs, Share-based Payments [Text Block] Warrants [Abstract] Warrants [Abstract] The entire disclosure for warrant liabilities. Warrants [Text Block] Commitments and Contingencies Disclosure [Abstract] Commitments and Contingencies Disclosure [Text Block] Licensing Transaction [Abstract] Licensing Transaction [Abstract] The entire disclosure for a contractual arrangement, in which the Company gave another party an exclusive license. Licensing Transaction [Text Block] Available-for-sale Securities [Table Text Block] Schedule of Unrealized Loss on Investments [Table Text Block] Investment Income [Table Text Block] Schedule of Accumulated Other Comprehensive Income (Loss) [Table Text Block] Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block] Schedule of Accrued Liabilities [Table Text Block] Schedule of Maturities of Long-term Debt [Table Text Block] Plan Name [Domain] Note 9 - Stockholders' Equity (Tables) [Table] Note 9 - Stockholders' Equity (Tables) [Line Items] Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] Schedule of Share-based Payment Award, Employee Stock Purchase Plan, Valuation Assumptions [Table Text Block] Schedule of Shar-based Compensation, Stock Options and Restricted Stock Awards, Activity [Table Text Block] Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block] Schedule of Common Stock Warrant Liability Valuation Assumptions [Table Text Block] Schedule of Common Stock Warranty Liability [Table Text Block] Short-Term Investment by Bond Maturities Short-Term Investment by Bond Maturities [Abstract] Maturities [Domain] Schedule of Available-for-sale Securities [Table] Schedule of Available-for-sale Securities [Line Items] Corporate bond maturities Corporate bond maturities [Abstract] Cost Fair value Investment Securities Gross Unrealized Losses and Fair Value by Investment Category Investment Securities Gross Unrealized Losses and Fair Value by Investment Category [Abstract] Note 5 - Investment Securities - Available For Sale (Details) - Investment Securities Gross Unrealized Losses and Fair Value by Investment Category [Table] Note 5 - Investment Securities - Available For Sale (Details) - Investment Securities Gross Unrealized Losses and Fair Value by Investment Category [Line Items] Available for Sale (all unrealized holding gains and losses are less than 12 months at date of measurement) Available for Sale (all unrealized holding gains and losses are less than 12 months at date of measurement) [Abstract] Available for sale securities with continuous gain position less than 12 months fair value. Bonds – corporate issuances with unrealized gains Aggregate Offering Price Bonds – corporate issuances with unrealized gains Bonds – corporate issuances with unrealized losses Bonds – corporate issuances with unrealized losses Total Total Investment Income Investment Income [Abstract] Interest and dividend income Realized losses Component of Accumulated Other Comprehensive Loss Component of Accumulated Other Comprehensive Loss [Abstract] Balance at Balance at Unrealized losses on investment securities Realized loss reclassified from other accumulated comprehensive loss Net other comprehensive loss, net Assets and Liabilities at Fair Value on a Recurring Basis Assets and Liabilities at Fair Value on a Recurring Basis [Abstract] Fair Value Hierarchy [Domain] Note 6 - Fair Value of Measurements (Details) - Assets and Liabilities at Fair Value on a Recurring Basis [Table] Note 6 - Fair Value of Measurements (Details) - Assets and Liabilities at Fair Value on a Recurring Basis [Line Items] Assets: Assets: [Abstract] Short-term investments available for sale Bonds – corporate issuances As of December 31, 2013 As of December 31, 2013 [Abstract] Liabilities: Liabilities: [Abstract] As of March 31, 2014 As of March 31, 2014 [Abstract] This element represents the portion of the balance sheet assertion valued at fair value by the entity whether such amount is presented as a separate caption or as a parenthetical disclosure. Additionally, this element may be used in connection with the fair value disclosures required in the footnote disclosures to the financial statements. The element may be used in both the balance sheet and disclosure in the same submission. This item represents common stock warrant liability as of the balance sheet date. Common stock warrant liability Other Accrued Liabilities Other Accrued Liabilities [Abstract] Amounts due to contract research organizations and other contractual agreements Accrued payroll and related benefits