| Date | Filer | Title | Filing | Type | Shares Traded | Price | Total Held |
|---|---|---|---|---|---|---|---|
| May 6, 2013 | SVP Investor Relations | Form 4 | Grant, award or other acquisition pursuant to Rule 16b-3(d) | 80,000 | -- | 300,000 | |
| December 3, 2015 | Ten Percent Owner | Form 4 | Open market or private sale of non-derivative or derivative security | 5,556 | $2.08 | 2,421,867 | |
| December 1, 2015 | Ten Percent Owner | Form 4 | Open market or private sale of non-derivative or derivative security | 15,000 | $2.15 | 2,427,423 | |
| November 30, 2015 | Ten Percent Owner | Form 4 | Open market or private sale of non-derivative or derivative security | 20,000 | $2.15 | 2,442,423 | |
| September 8, 2015 | Ten Percent Owner | Form 4 | Open market or private sale of non-derivative or derivative security | 10,000 | $2.11 | 2,462,423 | |
| August 17, 2015 | Ten Percent Owner | Form 4 | Open market or private sale of non-derivative or derivative security | 10,000 | $2.19 | 2,472,423 | |
| August 13, 2015 | Ten Percent Owner | Form 4 | Open market or private sale of non-derivative or derivative security | 20,000 | $2.23 | 2,482,423 | |
| August 5, 2015 | Ten Percent Owner | Form 4 | Open market or private sale of non-derivative or derivative security | 10,000 | $2.26 | 2,502,423 | |
| February 20, 2015 | Ten Percent Owner | Form 4 | Open market or private sale of non-derivative or derivative security | 199,765 | $3.30 | 2,512,423 | |
| June 27, 2014 | Ten Percent Owner | Form 3 | Initial Statement of Beneficial Ownership of Securities | -- | -- | 2,712,188 | |
| June 9, 2004 | Vice President,General Counsel | Form 4 | Grant, award or other acquisition pursuant to Rule 16b-3(d) | 200,000 | -- | 200,000 | |
| May 12, 2006 | VP - Clin. Dev. & Med. Affairs | Form 4 | Open market or private purchase of non-derivative or derivative security | 300 | $3.75 | 2,300 | |
| May 12, 2006 | VP - Clin. Dev. & Med. Affairs | Form 4 | Open market or private purchase of non-derivative or derivative security | 1,700 | $3.75 | 4,000 | |
| March 20, 2006 | VP - Clin. Dev. & Med. Affairs | Form 4 | Open market or private purchase of non-derivative or derivative security | 800 | $4.20 | 1,800 | |
| March 20, 2006 | VP - Clin. Dev. & Med. Affairs | Form 4 | Open market or private purchase of non-derivative or derivative security | 200 | $4.19 | 2,000 | |
| March 14, 2006 | VP - Clin. Dev. & Med. Affairs | Form 4/A | Open market or private purchase of non-derivative or derivative security | 200 | $4.05 | 200 | |
| March 14, 2006 | VP - Clin. Dev. & Med. Affairs | Form 4/A | Open market or private purchase of non-derivative or derivative security | 800 | $4.05 | 1,000 | |
| March 15, 2006 | VP - Operations | Form 4 | Grant, award or other acquisition pursuant to Rule 16b-3(d) | 4,534 | -- | 6,534 | |
| March 15, 2006 | VP - Operations | Form 4 | Grant, award or other acquisition pursuant to Rule 16b-3(d) | 3,500 | -- | 20,167 | |
| March 15, 2006 | VP - Operations | Form 4 | Grant, award or other acquisition pursuant to Rule 16b-3(d) | 2,000 | -- | 8,534 | |
| March 15, 2006 | VP - Regulatory Affairs | Form 4 | Grant, award or other acquisition pursuant to Rule 16b-3(d) | 2,369 | -- | 2,369 | |
| March 15, 2006 | VP - Regulatory Affairs | Form 4 | Grant, award or other acquisition pursuant to Rule 16b-3(d) | 3,500 | -- | 26,834 | |
| January 19, 2009 | VP & Chief Medical Officer | Form 4 | Grant, award or other acquisition pursuant to Rule 16b-3(d) | 5,000 | $2.72 | 19,000 | |
| January 19, 2009 | VP & Chief Medical Officer | Form 4 | Grant, award or other acquisition pursuant to Rule 16b-3(d) | 11,667 | $2.72 | 121,667 | |
| January 19, 2009 | VP & Chief Medical Officer | Form 4 | Grant, award or other acquisition pursuant to Rule 16b-3(d) | 11,667 | $2.72 | 133,334 |
For recent transactions, including derivative transactions, see our Section 16 SEC filings page.
* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.
