| Date | Filer | Title | Filing | Type | Shares Traded | Price | Total Held |
|---|---|---|---|---|---|---|---|
| March 4, 2005 | VP of Operations | Form 3 | Initial Statement of Beneficial Ownership of Securities | -- | -- | -- | |
| May 23, 2005 | Director | Form 4 | Open market or private purchase of non-derivative or derivative security | 44,300 | $0.40 | 664,395 | |
| May 24, 2005 | Director | Form 4 | Open market or private purchase of non-derivative or derivative security | 55,700 | $0.41 | 720,095 | |
| May 24, 2005 | Director | Form 4 | Open market or private purchase of non-derivative or derivative security | 20,000 | $0.42 | 148,346 | |
| May 25, 2005 | VP of Operations | Form 4 | Open market or private purchase of non-derivative or derivative security | 10,000 | $0.39 | 10,000 | |
| June 1, 2005 | Director, President and CEO | Form 4 | Bona fide gift | 1,000,000 | -- | 4,287,176 | |
| June 7, 2005 | Director, President and CEO | Form 4 | Bona fide gift | 995,500 | -- | 5,282,676 | |
| July 29, 2005 | President, CEO | Form 4 | Grant, award or other acquisition pursuant to Rule 16b-3(d) | 6,440,000 | -- | 6,440,000 | |
| July 29, 2005 | President, CEO | Form 3 | Initial Statement of Beneficial Ownership of Securities | -- | -- | 62,500 | |
| August 12, 2005 | Director | Form 4 | Grant, award or other acquisition pursuant to Rule 16b-3(d) | 50,000 | -- | 50,000 | |
| November 14, 2005 | EVP, CFO | Form 4 | Open market or private purchase of non-derivative or derivative security | 25,000 | $0.32 | 25,000 | |
| November 14, 2005 | President, CEO | Form 4 | Open market or private purchase of non-derivative or derivative security | 76,645 | $0.33 | 76,645 | |
| November 14, 2005 | President, CEO | Form 4/A | Open market or private purchase of non-derivative or derivative security | 76,645 | $0.33 | 139,145 | |
| November 15, 2005 | VP of Operations | Form 4 | Open market or private purchase of non-derivative or derivative security | 20,000 | $0.31 | 20,000 | |
| November 15, 2005 | VP of Operations | Form 4/A | Open market or private purchase of non-derivative or derivative security | 20,000 | $0.31 | 30,000 | |
| November 16, 2005 | EVP, CFO | Form 4/A | Open market or private purchase of non-derivative or derivative security | 3,700 | $0.29 | 210,367 | |
| November 16, 2005 | EVP, CFO | Form 4 | Open market or private purchase of non-derivative or derivative security | 3,700 | $0.29 | 3,700 | |
| November 16, 2005 | EVP, CFO | Form 4 | Open market or private purchase of non-derivative or derivative security | 21,300 | $0.29 | 21,300 | |
| November 17, 2005 | EVP, CFO | Form 4/A | Open market or private purchase of non-derivative or derivative security | 21,300 | $0.29 | 231,667 | |
| January 16, 2006 | VP of Clinical Development | Form 4 | Grant, award or other acquisition pursuant to Rule 16b-3(d) | 200,000 | -- | 200,000 | |
| March 3, 2006 | EVP, CFO | Form 4 | Open market or private purchase of non-derivative or derivative security | 2,500 | $4.28 | 17,944 | |
| March 14, 2006 | Director | Form 4 | Open market or private purchase of non-derivative or derivative security | 200 | $4.05 | 200 | |
| March 14, 2006 | Director | Form 4 | Open market or private purchase of non-derivative or derivative security | 800 | $4.05 | 1,000 | |
| March 14, 2006 | VP - Clin. Dev. & Med. Affairs | Form 4/A | Open market or private purchase of non-derivative or derivative security | 200 | $4.05 | 200 | |
| March 14, 2006 | VP - Clin. Dev. & Med. Affairs | Form 4/A | Open market or private purchase of non-derivative or derivative security | 800 | $4.05 | 1,000 |
For recent transactions, including derivative transactions, see our Section 16 SEC filings page.
* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.
