| Date | Filer | Title | Filing | Type | Shares Traded | Price | Total Held |
|---|---|---|---|---|---|---|---|
| February 22, 2005 | VP, General Counsel | Form 4 | Grant, award or other acquisition pursuant to Rule 16b-3(d) | 100,000 | -- | 300,000 | |
| March 15, 2007 | VP of Research & Development | Form 4 | Grant, award or other acquisition pursuant to Rule 16b-3(d) | 15,000 | -- | 33,434 | |
| February 23, 2007 | VP of Research & Development | Form 4 | Open market or private purchase of non-derivative or derivative security | 6,000 | $3.55 | 15,100 | |
| October 3, 2006 | VP of Research & Development | Form 4 | Grant, award or other acquisition pursuant to Rule 16b-3(d) | 5,100 | $2.44 | 9,100 | |
| October 3, 2006 | VP of Research & Development | Form 4 | Open market or private purchase of non-derivative or derivative security | 5,100 | -- | 18,434 | |
| February 24, 2005 | VP of Regulatory Affairs | Form 3 | Initial Statement of Beneficial Ownership of Securities | -- | -- | -- | |
| February 24, 2005 | VP of Regulatory Affairs | Form 3 | Initial Statement of Beneficial Ownership of Securities | -- | -- | -- | |
| November 15, 2005 | VP of Operations | Form 4/A | Open market or private purchase of non-derivative or derivative security | 20,000 | $0.31 | 30,000 | |
| November 15, 2005 | VP of Operations | Form 4 | Open market or private purchase of non-derivative or derivative security | 20,000 | $0.31 | 20,000 | |
| May 25, 2005 | VP of Operations | Form 4 | Open market or private purchase of non-derivative or derivative security | 10,000 | $0.39 | 10,000 | |
| March 4, 2005 | VP of Operations | Form 3 | Initial Statement of Beneficial Ownership of Securities | -- | -- | -- | |
| March 4, 2005 | VP of Operations | Form 3 | Initial Statement of Beneficial Ownership of Securities | -- | -- | -- | |
| January 16, 2006 | VP of Clinical Development | Form 4 | Grant, award or other acquisition pursuant to Rule 16b-3(d) | 200,000 | -- | 200,000 | |
| January 19, 2009 | VP & Chief Medical Officer | Form 4 | Grant, award or other acquisition pursuant to Rule 16b-3(d) | 5,000 | $2.72 | 19,000 | |
| January 19, 2009 | VP & Chief Medical Officer | Form 4 | Grant, award or other acquisition pursuant to Rule 16b-3(d) | 11,667 | $2.72 | 121,667 | |
| January 19, 2009 | VP & Chief Medical Officer | Form 4 | Grant, award or other acquisition pursuant to Rule 16b-3(d) | 11,667 | $2.72 | 133,334 | |
| January 19, 2009 | VP & Chief Medical Officer | Form 4 | Grant, award or other acquisition pursuant to Rule 16b-3(d) | 11,666 | $2.72 | 145,000 | |
| November 20, 2008 | VP & Chief Medical Officer | Form 4 | Open market or private purchase of non-derivative or derivative security | 5,596 | $2.50 | 14,000 | |
| November 19, 2008 | VP & Chief Medical Officer | Form 4 | Open market or private purchase of non-derivative or derivative security | 404 | $2.50 | 8,404 | |
| June 18, 2008 | VP & Chief Medical Officer | Form 4 | Open market or private purchase of non-derivative or derivative security | 3,000 | $4.10 | 8,000 | |
| June 17, 2008 | VP & Chief Medical Officer | Form 3 | Initial Statement of Beneficial Ownership of Securities | -- | -- | 5,000 | |
| June 17, 2008 | VP & Chief Medical Officer | Form 3 | Initial Statement of Beneficial Ownership of Securities | -- | -- | -- | |
| June 17, 2008 | VP & Chief Medical Officer | Form 3 | Initial Statement of Beneficial Ownership of Securities | -- | -- | -- | |
| June 17, 2008 | VP & Chief Medical Officer | Form 3 | Initial Statement of Beneficial Ownership of Securities | -- | -- | -- | |
| June 17, 2008 | VP & Chief Medical Officer | Form 3 | Initial Statement of Beneficial Ownership of Securities | -- | -- | -- |
For recent transactions, including derivative transactions, see our Section 16 SEC filings page.
* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.
