Date Filer Title Filing Type Shares Traded Price Total Held
January 16, 2006 VP of Clinical Development Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 200,000 -- 200,000
November 17, 2005 EVP, CFO Form 4/A Open market or private purchase of non-derivative or derivative security 21,300 $0.29 231,667
November 16, 2005 EVP, CFO Form 4/A Open market or private purchase of non-derivative or derivative security 3,700 $0.29 210,367
November 16, 2005 EVP, CFO Form 4 Open market or private purchase of non-derivative or derivative security 3,700 $0.29 3,700
November 16, 2005 EVP, CFO Form 4 Open market or private purchase of non-derivative or derivative security 21,300 $0.29 21,300
November 15, 2005 VP of Operations Form 4/A Open market or private purchase of non-derivative or derivative security 20,000 $0.31 30,000
November 15, 2005 VP of Operations Form 4 Open market or private purchase of non-derivative or derivative security 20,000 $0.31 20,000
November 14, 2005 EVP, CFO Form 4 Open market or private purchase of non-derivative or derivative security 25,000 $0.32 25,000
November 14, 2005 President, CEO Form 4/A Open market or private purchase of non-derivative or derivative security 76,645 $0.33 139,145
November 14, 2005 President, CEO Form 4 Open market or private purchase of non-derivative or derivative security 76,645 $0.33 76,645
August 12, 2005 Director Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 50,000 -- 50,000
July 29, 2005 President, CEO Form 3 Initial Statement of Beneficial Ownership of Securities -- -- 62,500
July 29, 2005 President, CEO Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 6,440,000 -- 6,440,000
June 7, 2005 Director, President and CEO Form 4 Bona fide gift 995,500 -- 5,282,676
June 1, 2005 Director, President and CEO Form 4 Bona fide gift 1,000,000 -- 4,287,176
May 25, 2005 VP of Operations Form 4 Open market or private purchase of non-derivative or derivative security 10,000 $0.39 10,000
May 24, 2005 Director Form 4 Open market or private purchase of non-derivative or derivative security 55,700 $0.41 720,095
May 24, 2005 Director Form 4 Open market or private purchase of non-derivative or derivative security 20,000 $0.42 148,346
May 23, 2005 Director Form 4 Open market or private purchase of non-derivative or derivative security 44,300 $0.40 664,395
March 4, 2005 VP of Operations Form 3 Initial Statement of Beneficial Ownership of Securities -- -- --
March 4, 2005 VP of Operations Form 3 Initial Statement of Beneficial Ownership of Securities -- -- --
February 24, 2005 VP of Regulatory Affairs Form 3 Initial Statement of Beneficial Ownership of Securities -- -- --
February 24, 2005 VP of Regulatory Affairs Form 3 Initial Statement of Beneficial Ownership of Securities -- -- --
February 22, 2005 Director, President and CEO Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 150,000 -- 2,100,000
February 22, 2005 Director, Chief Financial Officer Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 100,000 -- 1,820,000

For recent transactions, including derivative transactions, see our Section 16 SEC filings page.

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.