Date Filer Title Filing Type Shares Traded Price Total Held
March 20, 2006 VP - Clin. Dev. & Med. Affairs Form 4 Open market or private purchase of non-derivative or derivative security 200 $4.19 2,000
March 17, 2006 Director Form 4 Open market or private purchase of non-derivative or derivative security 10,000 $4.03 70,800
March 15, 2006 EVP-COO, CFO Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 10,478 -- 28,423
March 15, 2006 EVP-COO, CFO Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 33,000 -- 156,334
March 15, 2006 EVP-COO, CFO Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 20,000 -- 176,334
March 15, 2006 VP - Regulatory Affairs Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 2,369 -- 2,369
March 15, 2006 VP - Regulatory Affairs Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 3,500 -- 26,834
March 15, 2006 Director Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 6,127 -- 60,800
March 15, 2006 Director Form 4 Open market or private purchase of non-derivative or derivative security 8,578 -- 29,912
March 15, 2006 President & CEO Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 24,510 -- 33,786
March 15, 2006 President & CEO Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 13,000 -- 442,334
March 15, 2006 VP - Operations Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 4,534 -- 6,534
March 15, 2006 VP - Operations Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 3,500 -- 20,167
March 15, 2006 VP - Operations Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 2,000 -- 8,534
March 15, 2006 Director Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 3,676 -- 10,676
March 15, 2006 Director Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 3,676 -- 17,876
March 15, 2006 Director Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 3,676 -- 64,010
March 15, 2006 Director Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 3,676 -- 7,010
March 14, 2006 Director Form 4 Open market or private purchase of non-derivative or derivative security 200 $4.05 200
March 14, 2006 Director Form 4 Open market or private purchase of non-derivative or derivative security 800 $4.05 1,000
March 14, 2006 VP - Clin. Dev. & Med. Affairs Form 4/A Open market or private purchase of non-derivative or derivative security 200 $4.05 200
March 14, 2006 VP - Clin. Dev. & Med. Affairs Form 4/A Open market or private purchase of non-derivative or derivative security 800 $4.05 1,000
March 3, 2006 EVP, CFO Form 4 Open market or private purchase of non-derivative or derivative security 2,500 $4.28 17,944
January 16, 2006 VP of Clinical Development Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 200,000 -- 200,000
November 17, 2005 EVP, CFO Form 4/A Open market or private purchase of non-derivative or derivative security 21,300 $0.29 231,667

For recent transactions, including derivative transactions, see our Section 16 SEC filings page.

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.